{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:23:31Z","timestamp":1785867811258,"version":"3.56.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":4539,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Appetite and growth were studied in primary schoolboys (6\u201310 years) infected with<jats:italic>Ascaris lumbricoides<\/jats:italic>(86%) and<jats:italic>Trichuris trichiura<\/jats:italic>(100%) who received a single dose of pyrantel pamoate (which has little or no effect on<jats:italic>Trichuris trichiura<\/jats:italic>) or a placebo. Boys were examined, allocated at random by descending<jats:italic>Ascaris<\/jats:italic>egg count to pyrantel (PR,<jats:italic>n<\/jats:italic>= 36) or placebo (PL,<jats:italic>n<\/jats:italic>= 36) groups, treated, and re-examined 3 and 7 weeks later. The 2 groups did not differ significantly before treatment in helminth infections, appetite, or growth. Three and 7 weeks after treatment, the PR group exhibited significantly greater increases than did the PL group in weight (0\u00b72 kg and 0\u00b74 kg more, respectively) and percentage weight-for-age (0\u00b76% and 1\u00b77% points more, respectively). Appetite increased significantly in the PR group at 3 and 7 weeks (<jats:italic>P<\/jats:italic>&lt; 0\u00b70005 and<jats:italic>P<\/jats:italic>&lt; 0\u00b701, respectively) but not in the PL group. The prevalence and intensity of<jats:italic>A. lumbricoides<\/jats:italic>infection were greatly reduced in the PR group at 3 and 7 weeks (both<jats:italic>P<\/jats:italic>&lt; 0\u00b70001) but not in the PL group. We conclude that treatment with pyrantel pamoate may improve appetite and growth in schoolchildren in areas where<jats:italic>A. lumbricoides<\/jats:italic>infections and poor growth are highly prevalent.<\/jats:p>","DOI":"10.1017\/s0031182000081579","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T13:19:39Z","timestamp":1244207979000},"page":"497-504","source":"Crossref","is-referenced-by-count":48,"title":["Improvements in appetite and growth in helminth-infected schoolboys three and seven weeks after a single dose of pyrantel pamoate"],"prefix":"10.1017","volume":"113","author":[{"given":"V.","family":"Hadju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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