{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:36:51Z","timestamp":1765960611156},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,4,6]],"date-time":"2009-04-06T00:00:00Z","timestamp":1238976000000},"content-version":"unspecified","delay-in-days":7735,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Actively immunized mice, whole-body irradiated with 650 or 525 rad., manifested comparable levels of resistance to<jats:italic>Schistosoma mansoni<\/jats:italic>compared with unirradiated, immunized mice in spite of a marked reduction in circulating leucocytes (&gt;90%) and platelets (&gt;85%), and despite an abrogation of delayed-type hypersensitivity (DTH) (Type IV) response to schistosomular antigens (as determined by footpad swelling, 24 h after injection of antigen). However, limited histopathological comparison of lung sections from irradiated and unirradiated mice 7 days post-challenge showed that cellular reactions (\u2018foci\u2019) around parasites were essentially similar in size and cellular composition except that in irradiated mice, eosinophils were poorly represented both in the foci and in lung tissue in general. Neither presumed immune complex-mediated (Type III, Arthus reaction) hypersensitivity (as determined by footpad swelling, 5 h after injection of antigen) nor serum anti-schistosomulum extract antibody levels (as determined by ELISA) were affected. In addition, the pattern of<jats:sup>125<\/jats:sup>I-labelled schistosomular surface antigens immunoprecipitated with serum from irradiated and unirradiated mice was essentially similar. These results are consistent with antibody playing an important role in vaccine-induced immunity in mice but suggest that radiosensitive T cell function and radiosensitive cells, such as platelets and polymorphonuclear cells, including eosinophils, may not be essential.<\/jats:p>","DOI":"10.1017\/s0031182000081658","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T16:11:33Z","timestamp":1244218293000},"page":"49-61","source":"Crossref","is-referenced-by-count":23,"title":["Studies on immunity to<i>Schistosoma mansoni in vivo<\/i>: whole-body irradiation has no effect on vaccine-induced resistance in mice"],"prefix":"10.1017","volume":"96","author":[{"given":"D. A. A.","family":"Vignali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. D.","family":"Bickle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,4,6]]},"reference":[{"key":"S0031182000081658_ref033","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000063484"},{"key":"S0031182000081658_ref030","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052446"},{"key":"S0031182000081658_ref029","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.4049\/jimmunol.136.7.2644","article-title":"Passive transfer with serum and IgG antibodies of irradiated cercaria induced resistance against Schistosoma mansoni in mice","volume":"7","author":"Mangold","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000081658_ref028","doi-asserted-by":"publisher","DOI":"10.1084\/jem.142.4.805"},{"key":"S0031182000081658_ref032","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.4049\/jimmunol.128.4.1880","article-title":"Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement","volume":"128","author":"Sher","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000081658_ref026","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.128.4.1535","article-title":"Macrophages as effector cells of protective immunity in murine schistosomiasis. II. 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Correlation of resistance with induction of activated larvacidal macrophages","volume":"136","author":"James","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0031182000081658_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb00836.x"},{"key":"S0031182000081658_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051003"},{"key":"S0031182000081658_ref001","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830040309"},{"key":"S0031182000081658_ref007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0022-1759(84)90386-7","article-title":"A comparative study of total body irradiation as a method of inducing granulocyte depletion in mice","volume":"70","author":"Booman","year":"1984","journal-title":"Journal of Immunological Methods"},{"key":"S0031182000081658_ref005","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.4049\/jimmunol.128.5.2101","article-title":"Studies on the surface antigenicity and susceptibility to antibody-dependent killing of developing schistosomula using sera from chronically infected mice and mice vaccinated with irradiated cercariae","volume":"128","author":"Bickle","year":"1982","journal-title":"Journal of Immunology"},{"key":"S0031182000081658_ref009","doi-asserted-by":"crossref","first-page":"777","DOI":"10.4049\/jimmunol.125.2.777","article-title":"Defective tumoricidal capacity of macrophages from P\/J mice: tumoricidal defect involves abnormalities in lymphokine derived activation stimuli and in mononuclear phagocyte responsiveness","volume":"125","author":"Boraschi","year":"1980","journal-title":"Journal of Immunology"},{"key":"S0031182000081658_ref010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.127.1.1","article-title":"In vitro killing of S. mansoni schistosomula by lymphokine activated mouse macrophages","volume":"127","author":"Bout","year":"1981","journal-title":"Journal of Immunology"},{"key":"S0031182000081658_ref016","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.89"},{"key":"S0031182000081658_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053294"},{"key":"S0031182000081658_ref002","first-page":"215","volume-title":"Advances in Immunology","volume":"24","author":"Anderson","year":"1970"},{"key":"S0031182000081658_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60287-0"},{"key":"S0031182000081658_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90008-9"},{"key":"S0031182000081658_ref011","doi-asserted-by":"publisher","DOI":"10.1126\/science.3079916"},{"key":"S0031182000081658_ref008","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4049\/jimmunol.125.2.771","article-title":"Defective tumoricidal capacity of macrophages from P\/J mice: characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli","volume":"125","author":"Boraschi","year":"1980","journal-title":"Journal of Immunology"},{"key":"S0031182000081658_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1986.tb01038.x"},{"key":"S0031182000081658_ref022","first-page":"523","volume-title":"Genetic Control of Host Resistance to Injection and Malignancy","author":"James","year":"1985"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182000081658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:36:54Z","timestamp":1685025414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182000081658\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,2]]}},"alternative-id":["S0031182000081658"],"URL":"https:\/\/doi.org\/10.1017\/s0031182000081658","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2]]}}}