{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:09:15Z","timestamp":1771661355016,"version":"3.50.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T00:00:00Z","timestamp":1269561600000},"content-version":"unspecified","delay-in-days":5167,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This paper demonstrates that the activities of glycogen phosphorylase (GP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are reduced in adult worms of the filarial nematode<jats:italic>Litomosoides carinii<\/jats:italic>recovered from pyri-doxine-deficient cotton rats when compared to worms recovered from pyridoxine-sufficient controls. GP, ALT and AST activities were determined in adult worms<jats:italic>L. carinii<\/jats:italic>recovered from cotton rat hosts over a 20-week experimental period. Activities of GP, ALT and AST in the parasite showed a direct correlation with the dietary pyridoxine intake of their host. Throughout the experiment, enzyme activities were significantly lower (<jats:italic>P<\/jats:italic>&lt; 0\u00b7001) in worms from rats fed a pyridoxine-free diet<jats:italic>ad libitum<\/jats:italic>that in worms from rats fed either a stock colony diet, a pyridoxine-free diet<jats:italic>ad libitum<\/jats:italic>with daily supplementation of 100 \u03bcg pyridoxine or limited amounts of pyridoxine-free diet with daily supplementation of 100 \u03bcg pyridoxine. The lower than normal activity of GP, ALT, AST and other enzymes dependent on the biologically active derivative of pyridoxine, the coenzyme pyridoxal-5-phosphate (PLP), interferes with the protein, carbohydrate and lipid metabolism of<jats:italic>L. carinii<\/jats:italic>and may in part cause the reduced establishment, development and growth of the parasite in pyridoxine-deficient hosts.<\/jats:p>","DOI":"10.1017\/s0031182000084808","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T15:04:43Z","timestamp":1269615883000},"page":"227-232","source":"Crossref","is-referenced-by-count":3,"title":["Activities of glycogen phosphorylase, alanine aminotransferase and aspartate aminotransferase in adult worms of<i>Litomosoides carinii<\/i>recovered from pyridoxine deficient cotton rats (<i>Sigmodon hispidus<\/i>)"],"prefix":"10.1017","volume":"112","author":[{"given":"M. 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