{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:30:44Z","timestamp":1760819444816},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2002,6,18]],"date-time":"2002-06-18T00:00:00Z","timestamp":1024358400000},"content-version":"unspecified","delay-in-days":443,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>Injection trials with compatible and non-compatible <jats:italic>Onchocerca<\/jats:italic> species into<jats:italic> S. damnosum<\/jats:italic> s.l., the vector of human and bovine onchocerciasis, demonstrated that the rapid killing of microfilariae within the blackfly's haemocoel is species specific. In the presence of the peptide RGDS as a blocking agent for integrin-like receptors of haemocytes, the survival of <jats:italic>O. ochengi<\/jats:italic> microfilariae in its natural intermediate host was significantly increased. This increased survival 24 h p.i. correlated with a significant decrease of apoptosis levels in the microfilariae following a 2 h exposure to the haemolymph <jats:italic>in vivo<\/jats:italic>. These findings suggest that haemocytes are directly involved in the killing of <jats:italic>Onchocerca<\/jats:italic> microfilariae in the blackfly.<\/jats:p>","DOI":"10.1017\/s0031182001007545","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:17:11Z","timestamp":1027761431000},"page":"433-438","source":"Crossref","is-referenced-by-count":10,"title":["Integrin-like RGD-dependent cell adhesion mechanism is involved in the rapid killing of <i>Onchocerca<\/i> microfilariae during early infection of <i>Simulium damnosum<\/i> s.l."],"prefix":"10.1017","volume":"122","author":[{"given":"H. E.","family":"HAGEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"KL\u00c4GER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2002,6,18]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182001007545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,7]],"date-time":"2019-04-07T16:15:12Z","timestamp":1554653712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182001007545\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["S0031182001007545"],"URL":"https:\/\/doi.org\/10.1017\/s0031182001007545","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}