{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:03:03Z","timestamp":1775671383450,"version":"3.50.1"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2001,7,12]],"date-time":"2001-07-12T00:00:00Z","timestamp":994896000000},"content-version":"unspecified","delay-in-days":41,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>Resistance to <jats:italic>Ascaris suum<\/jats:italic> infections was investigated in 8- and 15-week-old Iberian pigs. Groups of 3 or 5 pigs were immunized weekly for 6 weeks with antigens of adult <jats:italic>A. suum: <\/jats:italic>a 97\u00a0kDa body wall (BW) fraction, a 42\u00a0kDa fraction of pseudocoelomic fluid (PF) or a 14\u00a0kDa PF-fraction; or were inoculated with increasing doses of infective eggs (500\u201320000), with or without abbreviation by pyrantel pamoate. All immunized pigs and unimmunized control pigs, were challenged with 10000 infective eggs 7 days after the last immunization. The number of liver lesions and lung larvae was substantially lower in the older pigs than in the younger ones 7 days after challenge, but the resistance in immunized pigs of both age groups was similar in comparison to the challenge controls of the same age. The highest degree of resistance against lung larvae was observed in pigs immunized with <jats:italic>A. suum<\/jats:italic> eggs (97\u201399%). The pigs immunized with the 14\u00a0kDa and 42\u00a0kDa PF-fractions were also well protected (67\u201393%), while no protection was produced by the 97\u00a0kDa BW fraction (0\u201349%). The reduction of white spots following immunization was less evident, with a maximum of 82% reduction in egg-inoculated young pigs.<\/jats:p>","DOI":"10.1017\/s0031182001007806","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:16:52Z","timestamp":1027775812000},"page":"699-707","source":"Crossref","is-referenced-by-count":15,"title":["Resistance against migrating <i>Ascaris suum <\/i>larvae in pigs immunized with infective eggs or adult worm antigens"],"prefix":"10.1017","volume":"122","author":[{"given":"F.\u00a0J.","family":"SERRANO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"REINA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"FRONTERA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"ROEPSTORFF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"NAVARRETE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2001,7,12]]},"reference":[{"key":"S0031182001007806_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90051-3"},{"key":"S0031182001007806_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(99)00007-2"},{"key":"S0031182001007806_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(92)90053-C"},{"key":"S0031182001007806_ref018","unstructured":"KENNEDY, M.\u00a0W. & QURESHI, F. (1986). Stage-specific secreted antigens of the parasitic larval stages of the nematode Ascaris. Immunology 58, 515\u2013522."},{"key":"S0031182001007806_ref006","doi-asserted-by":"crossref","unstructured":"DARAWSHE, S. , TSAFADYAH, Y. & DANIEL, E. (1987). Quaternary structure of erythrocruorin from the nematode Ascaris suum. Evidence for unsaturated haem-binding sites. The Biochemical Journal 242, 689\u2013694.","DOI":"10.1042\/bj2420689"},{"key":"S0031182001007806_ref031","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000073753"},{"key":"S0031182001007806_ref029","unstructured":"RONEUS, O. (1966). Studies on the aetiology and pathogenesis of white spots in the liver of pigs. Acta Veterinaria Scandinavica 7 (Suppl. 16), 1\u2013112."},{"key":"S0031182001007806_ref037","unstructured":"STROMBERG, B.\u00a0E. (1979). IgE and IgG1 antibody production by soluble products of Ascaris suum in the guinea-pig. 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Burgess Science Press, Basingstoke, UK."},{"key":"S0031182001007806_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(93)90046-I"},{"key":"S0031182001007806_ref030","doi-asserted-by":"crossref","unstructured":"SCHWARTZ, B. & ALICATA, J.\u00a0E. (1963). Ascaris larvae as a cause of liver and lung lesions in swine. Journal of Parasitology 19, 17\u201324.","DOI":"10.2307\/3271427"},{"key":"S0031182001007806_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(85)90028-1"},{"key":"S0031182001007806_ref016","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00261.x"},{"key":"S0031182001007806_ref033","unstructured":"STANKIEWICZ, M. & FROE, D.\u00a0L. (1995). Unabbreviated Ascaris suum immunizing infections of piglets lead to immunosuppression and increased numbers of intestinal parasites. 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