{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:45:01Z","timestamp":1768715101532,"version":"3.49.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2001,7,23]],"date-time":"2001-07-23T00:00:00Z","timestamp":995846400000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>Strong resistance to reinfection developed in pigs as a result of trickle inoculations with <jats:italic>Trichuris suis<\/jats:italic> (250 infective eggs twice weekly for 4 weeks). At challenge (4000 eggs) 8 weeks after the last trickle inoculation, we observed a 96% reduction in the mean number of established challenge worms in immunized (TRI\/CHA) compared with non-immunized controls (CON\/CHA) (74 v. 1753; <jats:italic>P<\/jats:italic> = 0\u00b7004). Moreover, the total faecal egg excretion was significantly lower in immunized pigs compared with controls (<jats:italic>P<\/jats:italic> = 0\u00b70003). The trickle inoculations depressed pig weight gains over the 8-week course of immunization (<jats:italic>P<\/jats:italic> = 0\u00b7042). It was observed that a small number of pigs developed a weaker level of resistance, reflecting the importance of genetic determinants. The relevance of these data to the population biology of porcine and human whipworm infections is discussed.<\/jats:p>","DOI":"10.1017\/s0031182001007934","type":"journal-article","created":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T15:58:26Z","timestamp":1035993506000},"page":"95-101","source":"Crossref","is-referenced-by-count":28,"title":["Acquired immunity to <i>Trichuris suis<\/i> infection in pigs"],"prefix":"10.1017","volume":"123","author":[{"given":"S.","family":"PEDERSEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"SAEED","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2001,7,23]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182001007934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:49:31Z","timestamp":1554320971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182001007934\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["S0031182001007934"],"URL":"https:\/\/doi.org\/10.1017\/s0031182001007934","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}