{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:56:51Z","timestamp":1791284211960,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2003,2,6]],"date-time":"2003-02-06T00:00:00Z","timestamp":1044489600000},"content-version":"unspecified","delay-in-days":462,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:p>Voltage-gated calcium (Ca<jats:sup>2+<\/jats:sup>) channels contribute to impulse propagation in excitable cells and also regulate intracellular levels of Ca<jats:sup>2+<\/jats:sup>. High voltage-activated (HVA) Ca<jats:sup>2+<\/jats:sup> channels are heteromultimeric membrane proteins. The pore-forming, voltage-sensing subunit is the \u03b1<jats:sub>1<\/jats:sub> subunit. We have cloned 3 HVA Ca<jats:sup>2+<\/jats:sup> channel \u03b1<jats:sub>1<\/jats:sub> subunit cDNAs from <jats:italic>Schistosoma mansoni.<\/jats:italic> One of these sequences most closely resembles the L-type class of HVA \u03b1<jats:sub>1<\/jats:sub> subunits. The other two sequences are most closely related to non L-type \u03b1<jats:sub>1<\/jats:sub> subunits. These schistosome \u03b1<jats:sub>1<\/jats:sub> subunits have many of the features common to HVA Ca<jats:sup>2+<\/jats:sup> channels, but also have distinct structural motifs. Analysis of the structural and functional properties of schistosome Ca<jats:sup>2+<\/jats:sup> channel subunits may provide information about these critical components of excitable cells.<\/jats:p>","DOI":"10.1017\/s0031182001008691","type":"journal-article","created":{"date-parts":[[2003,2,7]],"date-time":"2003-02-07T08:41:03Z","timestamp":1044607263000},"page":"489-497","source":"Crossref","is-referenced-by-count":33,"title":["Structure of three high voltage-activated calcium channel \u03b1<sub>1<\/sub> subunits from <i>Schistosoma mansoni<\/i>"],"prefix":"10.1017","volume":"123","author":[{"given":"A. B.","family":"KOHN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"LEA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"ROBERTS-MISTERLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A. V.","family":"ANDERSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M.","family":"GREENBERG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2003,2,6]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182001008691","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:43:42Z","timestamp":1557269022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182001008691\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0031182001008691"],"URL":"https:\/\/doi.org\/10.1017\/s0031182001008691","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,11]]}}}