{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:47:53Z","timestamp":1790905673911,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2003,1,16]],"date-time":"2003-01-16T00:00:00Z","timestamp":1042675200000},"content-version":"unspecified","delay-in-days":199,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>The process of host cell invasion by <jats:italic>Babesia divergens<\/jats:italic> is poorly understood and improved knowledge of the mechanism involved could lead to development of measures effective in disease prevention. To investigate parasite ligands on the erythrocyte surface, <jats:italic>B. divergens<\/jats:italic> cultures in bovine erythrocytes were transferred into enzyme-treated bovine, human, ovine and equine erythrocytes. Parasite invasion of bovine erythrocytes was not affected by trypsin treatment while treatment with alpha-chymotrypsin led to a reduction in parasite growth of 20\u201340%. Treatment of bovine and non-bovine erythrocytes with neuraminidase decreased their susceptibility to invasion by up to 97% implicating sialic acid as an important erythrocyte ligand for babesia, but the addition of either bovine or human <jats:italic>N<\/jats:italic>-acetylneuraminyl-lactose to <jats:italic>B. divergens<\/jats:italic> cultures in bovine erythrocytes had no inhibitory effect.<\/jats:p>","DOI":"10.1017\/s0031182002001798","type":"journal-article","created":{"date-parts":[[2002,10,30]],"date-time":"2002-10-30T11:01:45Z","timestamp":1035975705000},"page":"45-50","source":"Crossref","is-referenced-by-count":17,"title":["Chymotrypsin and neuraminidase treatment inhibits host cell invasion by <i>Babesia divergens<\/i> (Phylum <i>Apicomplexa<\/i>)"],"prefix":"10.1017","volume":"125","author":[{"given":"A.","family":"ZINTL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"WESTBROOK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u00a0E.","family":"SKERRETT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u00a0S.","family":"GRAY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"MULCAHY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2003,1,16]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182002001798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T15:56:43Z","timestamp":1554134203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182002001798\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["S0031182002001798"],"URL":"https:\/\/doi.org\/10.1017\/s0031182002001798","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}