{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:44:58Z","timestamp":1786999498495,"version":"build-2736575974"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2003,1,17]],"date-time":"2003-01-17T00:00:00Z","timestamp":1042761600000},"content-version":"unspecified","delay-in-days":261,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n                    A pleomorphic neoplasm (PN) is described from sections of\n                    <jats:italic>Onchocerca volvulus<\/jats:italic>\n                    worms in nodules excised from Cameroonian patients. PN is confined to older, non-fecund, female worms, and those classed as moribund\/dead. It is mainly composed of small, roundish, basophilic cells of diverse sizes, often forming a \u2018rosette\u2019 pattern around amorphous eosinophilic centres. The cells have a high nuclear\/cytoplasmic ratio and up to 2\u20133 mitoses\/high-power field; some become grossly enlarged, highly polymorphic and contain large, irregular blocks of chromatin. The eukaryotic PN cells first appear posteriorly in the pseudocoelom, probably from ovarian cells; they spread anteriorly, invading or compressing the uteri. Ivermectin treatment increased the prevalence PN from 3.7% of 1422 female worms in 637 patients before treatment to 17.5% of 1134 worms in 511 patients after 3 years treatment. Ivermectin at 400\u2013800\u00a0\u03bcg\/kg annually, or at 150\u00a0\u03bcg\/kg or 400\u2013800\u00a0\u03bcg\/kg 3-monthly, over 3 years, did not increase the PN prevalence significantly, as compared with standard doses of 150\u00a0\u03bcg\/kg annually. In other small series of African patients, PN prevalence increased in worms 2, 4, 6 and 10 months after ivermectin treatment; but there was no increase after treatment with amocarzine, albendazole or diethylcarbamazine and suramin. PN may partly account for the increased macrofilaricidal action of ivermectin on female\n                    <jats:italic>O. volvulus<\/jats:italic>\n                    in patients treated for 3 years at 3-monthly intervals.\n                  <\/jats:p>","DOI":"10.1017\/s0031182002002305","type":"journal-article","created":{"date-parts":[[2003,2,5]],"date-time":"2003-02-05T11:08:19Z","timestamp":1044443299000},"page":"431-444","source":"Crossref","is-referenced-by-count":22,"title":["Neoplastic change in\n                    <i>Onchocerca volvulus<\/i>\n                    and its relation to ivermectin treatment"],"prefix":"10.1017","volume":"125","author":[{"given":"B.\u00a0O.\u00a0L.","family":"DUKE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u00a0M.","family":"MARTY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u00a0L.","family":"PEET","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"GARDON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u00a0D.\u00a0S.","family":"PION","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"KAMGNO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"BOUSSINESQ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2003,1,17]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182002002305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T16:00:31Z","timestamp":1554134431000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182002002305\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0031182002002305"],"URL":"https:\/\/doi.org\/10.1017\/s0031182002002305","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}