{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:48:07Z","timestamp":1761310087592},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T00:00:00Z","timestamp":1051142400000},"content-version":"unspecified","delay-in-days":82,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>The parasitic female of <jats:italic>Strongyloides venezuelensis<\/jats:italic> keeps invading the epithelial layer of the host intestinal mucosa. Upon invasion, it adheres to the surface of the intestinal epithelial cells with adhesion molecules secreted from the mouth. It has been demonstrated that <jats:italic>S. venezuelensis<\/jats:italic> are expelled from the intestine because mucosal mast cells inhibit the attachment of adult worms to the mucosal surface. In the present study, we generated specific antibodies against secreted adhesion molecules to investigate their function <jats:italic>in vivo<\/jats:italic>, because these molecules have been demonstrated only <jats:italic>in vitro<\/jats:italic> in spite of the importance in the infection processes. A mouse monoclonal antibody specific to <jats:italic>S. venezuelensis<\/jats:italic> adhesion molecules inhibited the attachment of adult worms to plastic dishes and the binding of adhesion molecules to rat intestinal epithelial cells. Immunohistochemical study revealed that adhesion molecules were produced by oesophageal glands and were continuously secreted <jats:italic>in vivo<\/jats:italic> to line the wall of the tunnels formed by adult worms in the intestinal mucosa. Our findings indicate that adhesion molecules play essential roles in the infection processes of <jats:italic>S. venezuelensis<\/jats:italic> in the host intestine.<\/jats:p>","DOI":"10.1017\/s0031182002002718","type":"journal-article","created":{"date-parts":[[2003,3,3]],"date-time":"2003-03-03T06:11:03Z","timestamp":1046671863000},"page":"165-171","source":"Crossref","is-referenced-by-count":11,"title":["Secreted adhesion molecules of <i>Strongyloides venezuelensis<\/i> are produced by oesophageal glands and are components of the wall of tunnels constructed by adult worms in the host intestinal mucosa"],"prefix":"10.1017","volume":"126","author":[{"given":"H.","family":"MARUYAMA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"EL-MALKY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"KUMAGAI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"OHTA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2003,4,24]]},"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182002002718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T15:17:58Z","timestamp":1554563878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182002002718\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S0031182002002718"],"URL":"https:\/\/doi.org\/10.1017\/s0031182002002718","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}