{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:15:55Z","timestamp":1760782555734},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T00:00:00Z","timestamp":1066348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>In theory, the age at which maturation occurs in parasitic nematodes is inversely related to pre-maturational mortality rate, and cross-species data on mammalian nematodes are consistent with this prediction. Immunity is a major source of parasite mortality and parasites stand to gain sizeable fitness benefits through short-term adjustments of maturation time in response to variation in immune-mediated mortality. The effects of thymus-dependent immune responses on maturation in the nematode parasites <jats:italic>Strongyloides ratti<\/jats:italic> and <jats:italic>Nippostrongylus brasiliensis<\/jats:italic> were investigated using congenitally thymus-deficient (nude) rats. As compared with worms in normal rats, reproductive maturity of parasites (presence of eggs <jats:italic>in utero<\/jats:italic>) in nude rats occurred later in <jats:italic>S. ratti<\/jats:italic> but earlier in <jats:italic>N. brasiliensis<\/jats:italic>. Immune-mediated differences in maturation time were not associated with differences in worm length. Thymus-dependent immunity had no effect on pre-maturational mortality. Results are discussed in relation to theoretical expectations and possible explanations for the observed patterns in parasite maturation.<\/jats:p>","DOI":"10.1017\/s0031182003003998","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T09:42:48Z","timestamp":1066383768000},"page":"507-512","source":"Crossref","is-referenced-by-count":9,"title":["Host immune status affects maturation time in two nematode species \u2013 but not as predicted by a simple life-history model"],"prefix":"10.1017","volume":"127","author":[{"given":"M. A.","family":"GUINNEE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. W.","family":"GEMMILL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. H. K.","family":"CHAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"VINEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F.","family":"READ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2003,10,17]]},"reference":[{"key":"S0031182003003998_ref003","unstructured":"ANDERSON, R. M. (1988).The population biology and genetics of resistance to infection. In Genetics of Resistance to Bacterial and Parasitic Infection (ed. Wakelin, D. & Blackwell, J. ), pp. 233\u2013263.Taylor and Francis,London, UK."},{"key":"S0031182003003998_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005478"},{"key":"S0031182003003998_ref014","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065418"},{"key":"S0031182003003998_ref002","unstructured":"ANDERSON, R. C. (1992). Nematode Parasites of Vertebrates: Their Development and Transmission . 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