{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T09:32:27Z","timestamp":1706175147199},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T00:00:00Z","timestamp":1078272000000},"content-version":"unspecified","delay-in-days":2,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p>Experimental intraperitoneal<jats:italic>Taenia crassiceps<\/jats:italic>cysticercosis in mice exhibits distinct genetical, immunological and endocrinological features possibly resulting from the complex interactive network of their physiological systems. Very notable is the tendency of parasites to grow faster in hosts of the female sex. It is also remarkable in the feminization process that the infection induces in chronically infected male mice, characterized by their estrogenization, deandrogenization and loss of sexual and aggressive patterns of behaviour. The proto-oncogene<jats:italic>c-fos<\/jats:italic>is a sex steroid-regulated transcription factor gene, expressed basally and upon stimulation by many organisms. In the CNS of rodents,<jats:italic>c-fos<\/jats:italic>is found expressed in association to sexual stimulation and to various immunological and stressful events. Hence, we suspected that changes in<jats:italic>c-fos<\/jats:italic>expression in the brain could be involved in the feminization of the infected male mice. Indeed, it was found that<jats:italic>c-fos<\/jats:italic>expression increased at different times during infection in the hypothalamus, hippocampus, less so in the preoptic area and cortex, and not in several other organs. The significant and distinctive regional changes of<jats:italic>c-fos<\/jats:italic>in the CNS of infected mice indicate that the brain of the host senses intraperitoneal cysticercosis and may also announce its active participation in the regulation of the host\u2013parasite relationship. Possibly, the host's CNS activity is involved in the network that regulates the estrogenization and deandrogenization observed in the chronically infected male mice, as well as in the behavioural and immunological peculiarities observed in this parasitic infection.<\/jats:p>","DOI":"10.1017\/s0031182003004529","type":"journal-article","created":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T09:53:46Z","timestamp":1078307626000},"page":"343-351","source":"Crossref","is-referenced-by-count":10,"title":["Remote sensing of intraperitoneal parasitism by the host's brain: regional changes of<i>c-fos<\/i>gene expression in the brain of feminized cysticercotic male mice"],"prefix":"10.1017","volume":"128","author":[{"given":"J.","family":"MORALES-MONTOR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"ARRIETA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. I.","family":"DEL CASTILLO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"RODR\u00cdGUEZ-DORANTES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"CERB\u00d3N","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"LARRALDE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2004,3,3]]},"reference":[{"key":"S0031182003004529_ref033","doi-asserted-by":"crossref","unstructured":"WERSINGER, S. R. & RISSMAN, E. F. (2000).Oestrogen receptor alpha is essential for female-directed chemo-investigatory behaviour but is not required for the pheromone-induced luteinizing hormone surge in male mice.Journal of Neuroendocrinology 12, 103\u2013110.","DOI":"10.1046\/j.1365-2826.2000.00418.x"},{"key":"S0031182003004529_ref032","doi-asserted-by":"crossref","unstructured":"TOLEDO, A. , FRAGOSO, G. , ROSAS, G. , HERN\u00c1NDEZ, M. , GEVORKIAN, G. , L\u00d3PEZ-CASILLAS, F. , HERN\u00c1NDEZ, B. , ACERO, G. , HUERTA, M. , LARRALDE, C. & SCIUTTO, E. (2001).Two epitopes shared by Taenia crassiceps and Taenia solium confer protection against murine T. crassiceps cysticercosis along with a prominent Th1 response.Infection and Immunity 69, 1766\u20131773.","DOI":"10.1128\/IAI.69.3.1766-1773.2001"},{"key":"S0031182003004529_ref031","doi-asserted-by":"publisher","DOI":"10.2307\/3283192"},{"key":"S0031182003004529_ref027","doi-asserted-by":"publisher","DOI":"10.1007\/BF00930866"},{"key":"S0031182003004529_ref025","unstructured":"PAXINOS, G. & WATSON, C. (1998). The Rat Brain in Sterotaxic Coordinates ,5th Edn. Academic Press,New York."},{"key":"S0031182003004529_ref024","unstructured":"PAXINOS, G. , ASHWELL, K. W. S. & TORK, I. (1994). Atlas of the Developing Rat Nervous System ,3rd Edn. Academic Press,San Diego."},{"key":"S0031182003004529_ref023","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.5.G922"},{"key":"S0031182003004529_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00264-3"},{"key":"S0031182003004529_ref020","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050460"},{"key":"S0031182003004529_ref019","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.8.4527"},{"key":"S0031182003004529_ref018","doi-asserted-by":"crossref","unstructured":"MORALES-MONTOR, J. , BAIG, S. , KABBANI, A. & DAMIAN, R. T. (2002).Do interleukin-6 and macrophage migration inhibitory factor have a role during sex-associated susceptibility to cysticercosis?Parasitology Research 88, 901\u2013904.","DOI":"10.1007\/s00436-002-0674-8"},{"key":"S0031182003004529_ref017","doi-asserted-by":"publisher","DOI":"10.2307\/3283875"},{"key":"S0031182003004529_ref013","unstructured":"KUMEI, Y. , TODA, K. , KAWAUCHI, Y. , SHIMOKAWA, R. , SHIMOKAWA, H. & MAKITA, K. (2000).Nociceptive responses and immunohisto-chemical changes in the rat brain under gravity stress.Journal of Gravitational Physiology 7, 91\u2013102."},{"key":"S0031182003004529_ref012","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-j0003.1999"},{"key":"S0031182003004529_ref011","doi-asserted-by":"crossref","unstructured":"HYDER, S. M. , STANCEL, G. M. , NAWAZ, Z. , McDONNELL, D. P. & LOOSE-MITCHELL, D. S. (1992).Identification of an oestrogen response element in the 3\u2032-flanking region of the murine c-fos proto-oncogene.Journal of Biological Chemistry 267, 18047\u201318054.","DOI":"10.1016\/S0021-9258(19)37150-9"},{"key":"S0031182003004529_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(95)03581-Q"},{"key":"S0031182003004529_ref009","doi-asserted-by":"crossref","unstructured":"GOURBAL, B. E. , RIGHI, M. , PETIT, G. & GABRION, C. (2001).Parasite-altered host behaviour in the face of a predator: manipulation or not?Parasitology Research 87, 186\u2013192.","DOI":"10.1007\/PL00008573"},{"key":"S0031182003004529_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(00)00099-6"},{"key":"S0031182003004529_ref006","doi-asserted-by":"publisher","DOI":"10.1139\/z62-086"},{"key":"S0031182003004529_ref005","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-0114"},{"key":"S0031182003004529_ref003","doi-asserted-by":"publisher","DOI":"10.2307\/3283574"},{"key":"S0031182003004529_ref035","doi-asserted-by":"publisher","DOI":"10.1038\/ng859"},{"key":"S0031182003004529_ref026","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073374"},{"key":"S0031182003004529_ref008","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.308"},{"key":"S0031182003004529_ref015","unstructured":"LARRALDE, C. , SOTELO, J. , MONTOYA, R. M. , PALENCIA, G. , PADILLA, A. , GOVEZENSKY, T. , DIAZ, M. L. & SCIUTTO, E. (1990).Immunodiagnosis of human cysticercosis in cerebrospinal fluid: Antigens from murine Taenia crassiceps cysticerci effectively substitute those from porcine Taenia solium .Archives of Pathology and Laboratory Medicine 114, 926\u2013928."},{"key":"S0031182003004529_ref021","doi-asserted-by":"crossref","unstructured":"OLTVAI, Z. N. & BARABASI, A. L. (2002).Systems biology. Life's complexity pyramid.Science 25, 763\u2013764.","DOI":"10.1126\/science.1078563"},{"key":"S0031182003004529_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04000-3"},{"key":"S0031182003004529_ref001","unstructured":"BESEDOVSKY, H. O. & DEL REY, A. (2002).Introduction: immune-neuroendocrine network.Frontiers in Hormone Research 29, 1\u201314."},{"key":"S0031182003004529_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(95)00062-5"},{"key":"S0031182003004529_ref028","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.6.1231-b"},{"key":"S0031182003004529_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(72)90014-8"},{"key":"S0031182003004529_ref016","doi-asserted-by":"publisher","DOI":"10.1006\/expr.2000.4530"},{"key":"S0031182003004529_ref030","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021765713160"},{"key":"S0031182003004529_ref002","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.4.8137748"},{"key":"S0031182003004529_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(69)90086-1"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182003004529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:19:25Z","timestamp":1623716365000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182003004529\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0031182003004529"],"URL":"https:\/\/doi.org\/10.1017\/s0031182003004529","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}