{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:20:18Z","timestamp":1790698818515,"version":"4.1.0"},"reference-count":87,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2004,5,6]],"date-time":"2004-05-06T00:00:00Z","timestamp":1083801600000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>This paper presents a model-based analysis of longitudinal data describing the impact of integrated vector management on the intensity of<jats:italic>Wuchereria bancrofti<\/jats:italic>infection in Pondicherry, India. The aims of this analysis were (1) to gain insight into the dynamics of infection, with emphasis on the possible role of immunity, and (2) to develop a model that can be used to predict the effects of control. Using the LYMFASIM computer simulation program, two models with different types of immunity (anti-L3 larvae or anti-adult worm fecundity) were compared with a model without immunity. Parameters were estimated by fitting the models to data from 5071 individuals with microfilaria-density measurement before and after cessation of a 5-year vector management programme. A good fit, in particular of the convex shape of the age-prevalence curve, required inclusion of anti-L3 or anti-fecundity immunity in the model. An individual's immune-responsiveness was found to halve in ~10 years after cessation of boosting. Explanation of the large variation in Mf-density required considerable variation between individuals in exposure and immune responsiveness. The mean life-span of the parasite was estimated at about 10 years. For the post-control period, the models predict a further decline in Mf prevalence, which agrees well with observations made 3 and 6 years after cessation of the integrated vector management programme.<\/jats:p>","DOI":"10.1017\/s0031182004004822","type":"journal-article","created":{"date-parts":[[2004,5,6]],"date-time":"2004-05-06T12:53:51Z","timestamp":1083848031000},"page":"467-482","source":"Crossref","is-referenced-by-count":62,"title":["The dynamics of<i>Wuchereria bancrofti<\/i>infection: a model-based analysis of longitudinal data from Pondicherry, India"],"prefix":"10.1017","volume":"128","author":[{"given":"S.","family":"SUBRAMANIAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. A.","family":"STOLK","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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(1994).Cumulative exposure and its relationship with chronic filarial disease in bancroftian filariasis.Southeast Asian Journal of Tropical Medicine and Public Health 25, 516\u2013521."},{"key":"S0031182004004822_ref023","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000060613"},{"key":"S0031182004004822_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(91)90090-J"},{"key":"S0031182004004822_ref047","doi-asserted-by":"crossref","unstructured":"MICHAEL, E. , SIMONSEN, P. E. , MALECELA, M. , JAOKO, W. G. , PEDERSEN, E. M. , MUKOKO, D. , RWEGOSHORA, R. T. & MEYROWITSCH, D. W. 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