{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:46:13Z","timestamp":1791215173816,"version":"4.1.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T00:00:00Z","timestamp":1096934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>We investigated the genotypic composition of the digenetic parasite <jats:italic>Schistosoma mansoni<\/jats:italic> for its adult stages within the definitive host (the wild rat, <jats:italic>Rattus rattus<\/jats:italic>) and for the larval stages within the intermediate host (the snail, <jats:italic>Biomphalaria glabrata<\/jats:italic>) both collected at the same transmission site. Our analyses are based upon the recognition and distribution of 200 different multilocus genotypes generated by RAPD markers. While intramolluscan larval infrapopulations are characterized by a low infection rate (0\u00b76% on average) and low intra-host genetic diversity (1\u00b71 genotype on average per infected snail), adult infrapopulations within rats showed a high infection rate (94%) and a substantial intra-host genetic diversity (34 genotypes on average) linked to high intensities (160 worms per host on average). A single definitive host bearing 105 different genotypes harboured 52% of the total genetic diversity detected within the whole parasite population. Analysis of the genetic data allowed the identification of various ecological, behavioural and immunological factors which are likely to enhance transmission of multiple parasite genotypes towards the vertebrate hosts. From the distribution of repeated identical multilocus genotypes within the parasite population and among the hosts, we have inferred different parameters of the cercarial transmission efficiency as well as patterns and processes by which vertebrate hosts acquire infection in the field.<\/jats:p>","DOI":"10.1017\/s0031182004005943","type":"journal-article","created":{"date-parts":[[2004,10,13]],"date-time":"2004-10-13T17:36:35Z","timestamp":1097688995000},"page":"571-585","source":"Crossref","is-referenced-by-count":79,"title":["Molecular ecology of <i>Schistosoma mansoni<\/i> transmission inferred from the genetic composition of larval and adult infrapopulations within intermediate and definitive hosts"],"prefix":"10.1017","volume":"129","author":[{"given":"A.","family":"THERON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"SIRE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"ROGNON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"PRUGNOLLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"DURAND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2004,10,5]]},"reference":[{"key":"S0031182004005943_ref004","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2001)087[0762:GDOAPO]2.0.CO;2"},{"key":"S0031182004005943_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182002002020"},{"key":"S0031182004005943_ref013","unstructured":"MULVEY, M. , AHO, J. M. , LYDEARD, C. , LEBERG, P. L. & SMITH, M. H. (1991).Comparative population genetic structure of a parasite (Fascioloides magna) and its definitive host.Evolution 45, 1628\u20131640."},{"key":"S0031182004005943_ref010","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1967.16.483"},{"key":"S0031182004005943_ref018","unstructured":"POULIN, R. (1998). Evolutionary Ecology of Parasites .Chapman and Hall, London."},{"key":"S0031182004005943_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000064970"},{"key":"S0031182004005943_ref025","unstructured":"TH\u00c9RON, A. & POINTIER, J.-P. (1995).Ecology, dynamics, genetics and divergence of trematode populations in heterogenous environments: the model of Schistosoma mansoni in the insular focus of Guadeloupe.Research and Review in Parasitology 55, 49\u201364."},{"key":"S0031182004005943_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(93)90060-C"},{"key":"S0031182004005943_ref016","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1979541043"},{"key":"S0031182004005943_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(97)00670-0"},{"key":"S0031182004005943_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005417"},{"key":"S0031182004005943_ref019","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-294X.2002.01518.x"},{"key":"S0031182004005943_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006399X"},{"key":"S0031182004005943_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60425-X"},{"key":"S0031182004005943_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006755X"},{"key":"S0031182004005943_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(99)01553-7"},{"key":"S0031182004005943_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099004722"},{"key":"S0031182004005943_ref009","doi-asserted-by":"publisher","DOI":"10.1515\/mamm.1981.45.3.275"},{"key":"S0031182004005943_ref024","unstructured":"TH\u00c9RON, A. , PAG\u00c8S, J. R. & ROGNON, A. (1997). Schistosoma mansoni: distribution patterns of miracidia among Biomphalaria glabrata snail hosts as related to host susceptibility and sporocyst regulation process.Experimental Parasitology 85, 1\u20139."},{"key":"S0031182004005943_ref011","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0232:DOSIIM]2.0.CO;2"},{"key":"S0031182004005943_ref014","doi-asserted-by":"publisher","DOI":"10.2307\/3283821"},{"key":"S0031182004005943_ref021","doi-asserted-by":"publisher","DOI":"10.2307\/3285775"},{"key":"S0031182004005943_ref022","doi-asserted-by":"crossref","unstructured":"SIRE, C. , DURAND, P. , POINTIER, J.-P. & TH\u00c9RON, A. (2001 a).Genetic diversity of Schistosoma mansoni within and between individual hosts (Rattus rattus): infrapopulation differentiation at microspatial scale.International Journal for Parasitology 31, 1609\u20131616.","DOI":"10.1016\/S0020-7519(01)00294-6"},{"key":"S0031182004005943_ref023","doi-asserted-by":"crossref","unstructured":"SIRE, C. , LANGAND, J. , BARRAL, V. & TH\u00c9RON, A. (2001 b).Parasite (Schistosoma mansoni) and host (Biomphalaria glabrata) genetic diversity: population structure in a fragmented landscape.Parasitology 122, 545\u2013554.","DOI":"10.1017\/S0031182001007727"},{"key":"S0031182004005943_ref020","doi-asserted-by":"crossref","unstructured":"SIRE, C. , ROGNON, A. & THERON, A. (1998).Failure of Schistosoma mansoni to reinfect Biomphalaria glabrata snails: acquired humoral resistance or intra-specific larval antagonism?Parasitology 117, 117\u2013122.","DOI":"10.1017\/S0031182098002923"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182004005943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T19:56:50Z","timestamp":1557172610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182004005943\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0031182004005943"],"URL":"https:\/\/doi.org\/10.1017\/s0031182004005943","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,5]]}}}