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Prophylactic administration of vitamin C (50, 100 and 250 mg\/kg) from day15 to day 0 (15 doses) significantly reduced the intake of<jats:italic>Leishmania donovani<\/jats:italic>in hamsters but had no therapeutic effect. In contrast, vitamins A,B complex and E and iron, whether used prophylactically or therapeutically, promoted parasite multiplication. The efficacy of sodium stibogluconate, a reference antileishmanial drug, was appreciably improved in animals administered prophylactically with vitamin C. However, supplementation of vitamin C during established infections resulted in reduced drug action. The results show that the prophylactic use of vitamin C may prevent the onset of leishmania infection and cautions against the indiscriminate use of nutrient supplements such as vitamin A, B complex, and E and iron in VL endemic areas.<\/jats:p>","DOI":"10.1017\/s0031182004006055","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T14:45:36Z","timestamp":1100789136000},"page":"685-691","source":"Crossref","is-referenced-by-count":21,"title":["Intake of nutrient supplements affects multiplication of<i>Leishmania donovani<\/i>in hamsters"],"prefix":"10.1017","volume":"129","author":[{"given":"RAVENDRA","family":"GARG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NIRPENDRA","family":"SINGH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANURADHA","family":"DUBE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2004,11,18]]},"reference":[{"key":"S0031182004006055_ref056","doi-asserted-by":"publisher","DOI":"10.1007\/BF01941270"},{"key":"S0031182004006055_ref055","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/140.2.215"},{"key":"S0031182004006055_ref050","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(88)90164-0"},{"key":"S0031182004006055_ref053","doi-asserted-by":"publisher","DOI":"10.1139\/o89-084"},{"key":"S0031182004006055_ref048","unstructured":"SHARMA, P. , ANURADHA , SHARAN, R. , HAQ, W. , KUNDU, B. , KATIYAR, J. 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