{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T22:10:04Z","timestamp":1682892604007},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T00:00:00Z","timestamp":1102896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>Fatal murine cerebral malaria is an encephalitis and not simply a local manifestation in the brain of a systemic process. Histopathologically, murine cerebral malaria has been characterized by monocyte adherence to the endothelium of the microvasculature, activation of microglial cells, swelling of endothelial cell nuclei, microvasculature damage, and breakdown of the blood-brain barrier with cerebral oedema. Brain parenchymal cells have been proposed to be actively involved in the pathogenesis of murine cerebral malaria. We, therefore, compared the neurochemical characteristics of<jats:italic>Plasmodium berghei<\/jats:italic>ANKA-infected mice with controls to determine whether cerebral malarial infection significantly impairs specific neuronal populations. Between 6 and 7 days after infection, we found a significant loss of neurones containing substance P, with preservation of cells containing somatostatin, neuropeptide Y and calbindin in the striatum of infected mice compared with controls. In the cortex of infected mice, we found a significant reduction in the number of cells containing substance P, somatostatin and neuropeptide Y. The number of calbindin-containing neurones was unchanged. This study found significant changes in the neurochemical characteristics of the cortex and striatum of mice infected with<jats:italic>P. berghei<\/jats:italic>ANKA, which may contribute to their cerebral symptoms.<\/jats:p>","DOI":"10.1017\/s0031182004006237","type":"journal-article","created":{"date-parts":[[2004,12,14]],"date-time":"2004-12-14T09:26:57Z","timestamp":1103016417000},"page":"23-29","source":"Crossref","is-referenced-by-count":2,"title":["Differences in the neurochemical characteristics of the cortex and striatum of mice with cerebral malaria"],"prefix":"10.1017","volume":"130","author":[{"given":"C. J.","family":"CLARK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"PHILLIPS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. B.","family":"McMILLAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. O.","family":"MONTGOMERY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. W.","family":"STONE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2004,12,13]]},"reference":[{"key":"S0031182004006237_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00322-1"},{"key":"S0031182004006237_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(81)90587-2"},{"key":"S0031182004006237_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(92)90043-K"},{"key":"S0031182004006237_ref008","doi-asserted-by":"publisher","DOI":"10.1038\/327326a0"},{"key":"S0031182004006237_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80086-0"},{"key":"S0031182004006237_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00494-P"},{"key":"S0031182004006237_ref007","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.7.3532"},{"key":"S0031182004006237_ref014","doi-asserted-by":"crossref","unstructured":"GRAU, G. E. , PIGUET, P. F. , ENGERS, H. D. , LOUIS, J. A. , VASSALLI, P. & LAMBERT, P. H. (1986).L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria.Journal of Immunology 137,2348\u20132354.","DOI":"10.4049\/jimmunol.137.7.2348"},{"key":"S0031182004006237_ref009","doi-asserted-by":"crossref","unstructured":"DOBBIE, M. , CRAWLEY, J. , WARUIRU, C. , MARSH, K. & SURTEES, R. (2000).Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?American Journal of Tropical Medicine and Hygiene 62,284\u2013290.","DOI":"10.4269\/ajtmh.2000.62.284"},{"key":"S0031182004006237_ref032","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(82)90203-6"},{"key":"S0031182004006237_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00229-1"},{"key":"S0031182004006237_ref030","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000068050"},{"key":"S0031182004006237_ref023","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199702)19:2<135::AID-GLIA5>3.0.CO;2-#"},{"key":"S0031182004006237_ref022","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1997.00290.x"},{"key":"S0031182004006237_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)91199-7"},{"key":"S0031182004006237_ref025","unstructured":"MEDANA, I. M. , HUNT, N. H. & CHAUDHRI, G. (1997).Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes.American Journal of Pathology 150,1473\u20131486."},{"key":"S0031182004006237_ref019","doi-asserted-by":"crossref","unstructured":"JENNINGS, V. M. , LAL, A. A. & HUNTER, R. L. (1998).Evidence for multiple pathologic and protective mechanisms of murine cerebral malaria.Infection and Immunity 66,5972\u20135979.","DOI":"10.1128\/IAI.66.12.5972-5979.1998"},{"key":"S0031182004006237_ref003","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-06-01649.1991"},{"key":"S0031182004006237_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90120-O"},{"key":"S0031182004006237_ref011","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1994.1145"},{"key":"S0031182004006237_ref002","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890030106"},{"key":"S0031182004006237_ref036","unstructured":"STONE, T. W. (1993).Neuropharmacology of quinolinic and kynurenic acids.Pharmacological Reviews 45,309\u2013379."},{"key":"S0031182004006237_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90066-2"},{"key":"S0031182004006237_ref026","doi-asserted-by":"crossref","unstructured":"MEDANA, I. M. , HIEN, T. T. , DAY, N. P. , PHU, N. H. , MAI, N. T. H. , VAN CHU'ONG, L. , CHAU, T. T. H. , TAYLOR, A. , SALAHIFAR, H. , STOCKER, R. , SMYTHE, G. , TURNER, G. D. H. , FARRAR, J. , WHITE, N. J. & HUNT, N. H. (2002 a).The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria.Journal of Infectious Diseases 185,650\u2013656.","DOI":"10.1086\/339009"},{"key":"S0031182004006237_ref027","doi-asserted-by":"crossref","unstructured":"MEDANA, I. M. , DAY, N. P. , HIEN, T. T. , MAI, N. T. H. , BETHELL, D. , PHU, N. H. , FARRAR, J. , ESIRI, M. M. , WHITE, N. J. & TURNER, G. D. (2002 b).Axonal injury in cerebral malaria.American Journal of Pathology 160,655\u2013666.","DOI":"10.1016\/S0002-9440(10)64885-7"},{"key":"S0031182004006237_ref015","doi-asserted-by":"publisher","DOI":"10.1179\/135100000101535384"},{"key":"S0031182004006237_ref029","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000074072"},{"key":"S0031182004006237_ref020","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-17-06963.1998"},{"key":"S0031182004006237_ref040","doi-asserted-by":"crossref","unstructured":"TOHGI, H. , UTSUGISAWA, K. , YOSHIMURA, M. , YAMAGATA, M. , NAGANE, Y. & SAITOH, K. (1997).Reduction in the ratio of \u03b2-preprotachykinin to preproenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism.Brain Research 768,86\u201390.","DOI":"10.1016\/S0006-8993(97)00570-2"},{"key":"S0031182004006237_ref034","doi-asserted-by":"publisher","DOI":"10.1126\/science.6849138"},{"key":"S0031182004006237_ref037","unstructured":"STONE, T. W. (1995). Neuropharmacology , 1st Edn.W. H. Freeman and Company Limited,Oxford."},{"key":"S0031182004006237_ref038","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00032-0"},{"key":"S0031182004006237_ref039","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080203"},{"key":"S0031182004006237_ref041","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92658-X"},{"key":"S0031182004006237_ref012","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6549"},{"key":"S0031182004006237_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(87)90284-8"},{"key":"S0031182004006237_ref018","doi-asserted-by":"crossref","unstructured":"JENNINGS, V. M. , ACTOR, J. K. , LAL, A. A. & HUNTER, R. L. (1997).Cytokine profile suggesting that murine cerebral malaria is an encephalitis.Infection and Immunity 65,4883\u20134887.","DOI":"10.1128\/IAI.65.11.4883-4887.1997"},{"key":"S0031182004006237_ref031","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198703000-00009"},{"key":"S0031182004006237_ref028","doi-asserted-by":"publisher","DOI":"10.1086\/377583"},{"key":"S0031182004006237_ref006","unstructured":"CHANG-LING, T. , NEILL, A. L. & HUNT, N. H. (1992).Early microvascular changes in murine cerebral malaria detected in retinal wholemounts.American Journal of Pathology 140,1121\u20131130."},{"key":"S0031182004006237_ref033","unstructured":"SANNI, L. A. , THOMAS, S. R. , TATTAM, B. N. , MOORE, D. E. , CHAUDHRI, G. , STOCKER, R. & HUNT, N. H. (1998).Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.American Journal of Pathology 152,611\u2013619."}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182004006237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T21:42:54Z","timestamp":1682890974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182004006237\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,13]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0031182004006237"],"URL":"https:\/\/doi.org\/10.1017\/s0031182004006237","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,13]]}}}