{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:33:35Z","timestamp":1790249615937,"version":"4.1.0"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T00:00:00Z","timestamp":1103155200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p><jats:italic>Trichinella spiralis<\/jats:italic> infection causes the transformation of infected muscle cells, which leads to nurse cell formation. To search for the candidate genes responsible for nurse cell formation, cDNA microarray analysis of muscle tissues was performed before and after <jats:italic>Trichinella<\/jats:italic> infection. The Atlas mouse 1.2 cDNA expression microarray revealed the expression profiles of 1176 known genes. Out of these, 311 gene expressions were detected in normal and\/or infected muscles. After the infection, 184 out of the 311 genes increased in expression by more than 3-fold. These included genes responsible for cell differentiation, proliferation, cell cycle and apoptosis. Thus this study suggested candidate genes for further investigation to dissect the molecular mechanisms of nurse cell formation.<\/jats:p>","DOI":"10.1017\/s0031182004006912","type":"journal-article","created":{"date-parts":[[2005,4,12]],"date-time":"2005-04-12T13:07:42Z","timestamp":1113311262000},"page":"561-573","source":"Crossref","is-referenced-by-count":24,"title":["A spectrum of functional genes mobilized after <i>Trichinella spiralis<\/i> infection in skeletal muscle"],"prefix":"10.1017","volume":"130","author":[{"given":"Z.","family":"WU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"NAGANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"BOONMARS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"TAKAHASHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2004,12,16]]},"reference":[{"key":"S0031182004006912_ref028","doi-asserted-by":"crossref","unstructured":"MATUSHANSKY, I. , RADPARVAR, F. & SKOULTCHI, A. I. (2000).Manipulating the onset of cell cycle withdrawal in differentiated erythroid cells with cyclin-dependent kinases and inhibitors.Blood 96,2755\u20132764.","DOI":"10.1182\/blood.V96.8.2755"},{"key":"S0031182004006912_ref025","doi-asserted-by":"crossref","unstructured":"LEVINOVITZ, A. , JENNISCHE, E. , OLDFORS, A. , EDWALL, D. & NORSTEDT, G. (1992).Activation of insulin-like growth factor II expression during skeletal muscle regeneration in the rat: correlation with myotube formation.Molecular Endocrinology 6,1227\u20131234.","DOI":"10.1210\/mend.6.8.1406701"},{"key":"S0031182004006912_ref037","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9565"},{"key":"S0031182004006912_ref034","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1997.4180"},{"key":"S0031182004006912_ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099006198"},{"key":"S0031182004006912_ref008","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0416"},{"key":"S0031182004006912_ref039","doi-asserted-by":"crossref","unstructured":"SONG, K. , WANG, Y. & SASSOON, D. (1992).Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation.Nature, London 360,477\u2013481.","DOI":"10.1038\/360477a0"},{"key":"S0031182004006912_ref009","unstructured":"DESPOMMIER, D. D. (1975).Adaptive changes in muscle fibers infected with Trichinella spiralis .American Journal of Pathology 78,477\u2013496."},{"key":"S0031182004006912_ref040","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.209"},{"key":"S0031182004006912_ref005","doi-asserted-by":"crossref","unstructured":"BOONMARS, T. , WU, Z. , NAGANO, I. & TAKAHASHI, Y. (2004 b).Expression of apoptosis-related factors in muscles infected with T. spiralis .Parasitology 128,323\u2013332.","DOI":"10.1017\/S0031182003004530"},{"key":"S0031182004006912_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006042X"},{"key":"S0031182004006912_ref011","doi-asserted-by":"crossref","unstructured":"DESPOMMIER, D. D. (1998).How does Trichinella spiralis make itself at home?Parasitology Today 14,318\u2013323.","DOI":"10.1016\/S0169-4758(98)01287-3"},{"key":"S0031182004006912_ref047","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(98)00082-6"},{"key":"S0031182004006912_ref020","doi-asserted-by":"publisher","DOI":"10.1038\/381643a0"},{"key":"S0031182004006912_ref026","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.2.142"},{"key":"S0031182004006912_ref015","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.16.2040"},{"key":"S0031182004006912_ref044","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200208151-00002"},{"key":"S0031182004006912_ref003","doi-asserted-by":"crossref","unstructured":"BENDALL, A. J. , DING, J. , HU, G. , SHEN, M. M. & ABATE-SHEN, C. (1999).Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors.Development 126,4965\u20134976.","DOI":"10.1242\/dev.126.22.4965"},{"key":"S0031182004006912_ref021","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.121.4.785"},{"key":"S0031182004006912_ref017","unstructured":"GABRYEL, P. , GUSTOWSKA, L. & BLOTNA-FILIPIAK, M. (1995).The unique and specific transformation of muscle cell infected with Trichinella spiralis .Basic and Applied Myology 5,213\u2013222."},{"key":"S0031182004006912_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)00036-8"},{"key":"S0031182004006912_ref010","doi-asserted-by":"publisher","DOI":"10.2307\/3283370"},{"key":"S0031182004006912_ref014","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.2.431"},{"key":"S0031182004006912_ref018","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.2.534"},{"key":"S0031182004006912_ref004","doi-asserted-by":"crossref","unstructured":"BOONMARS, T. , WU, Z. , NAGANO, I. , NAKADA, T. & TAKAHASHI, Y. (2004 a).Differences and similarities of nurse cells in cysts of T. spiralis and T. pseudospiralis .Journal of Helminthology 78,7\u201316.","DOI":"10.1079\/JOH2003203"},{"key":"S0031182004006912_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(96)00042-X"},{"key":"S0031182004006912_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00212-9"},{"key":"S0031182004006912_ref006","doi-asserted-by":"publisher","DOI":"10.2307\/3284472"},{"key":"S0031182004006912_ref036","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.3.290"},{"key":"S0031182004006912_ref035","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1994.Supplement_18.10"},{"key":"S0031182004006912_ref019","doi-asserted-by":"crossref","unstructured":"HU, G. , LEE, H. , PRICE, S. M. , SHEN, M. M. & ABATE-SHEN, C. (2001).Msx homeobox genes inhibit differentiation through upregulation of cyclin D1.Development 128,2373\u20132384.","DOI":"10.1242\/dev.128.12.2373"},{"key":"S0031182004006912_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041570216"},{"key":"S0031182004006912_ref001","doi-asserted-by":"crossref","unstructured":"ABATE-SHEN, C. (2002).Deregulated homeobox gene expression in cancer: cause or consequence?Nature Reviews Cancer 2,777\u2013785.","DOI":"10.1038\/nrc907"},{"key":"S0031182004006912_ref045","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182001007958"},{"key":"S0031182004006912_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90395-6"},{"key":"S0031182004006912_ref032","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1109"},{"key":"S0031182004006912_ref022","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800805"},{"key":"S0031182004006912_ref046","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81261-1"},{"key":"S0031182004006912_ref016","doi-asserted-by":"crossref","unstructured":"FRIDAY, B. B. & PAVLATH, G. K. (2001).A calcineurin- and NFAT-dependent pathway regulates Myf5 gene expression in skeletal muscle reserve cells.Journal of Cell Science 114,303\u2013310.","DOI":"10.1242\/jcs.114.2.303"},{"key":"S0031182004006912_ref023","doi-asserted-by":"publisher","DOI":"10.1007\/BF00124351"},{"key":"S0031182004006912_ref007","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.20.12109"},{"key":"S0031182004006912_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(90)90005-W"},{"key":"S0031182004006912_ref041","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5252"},{"key":"S0031182004006912_ref043","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90033-0"},{"key":"S0031182004006912_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/3282565"},{"key":"S0031182004006912_ref048","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(97)00199-0"},{"key":"S0031182004006912_ref042","unstructured":"WEINBERG, R. A. (1996).The molecular basis of carcinogenesis: understanding the cell cycle clock.Cytokines Molecular Therapy 2,105\u2013110."},{"key":"S0031182004006912_ref038","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041590222"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182004006912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T23:10:01Z","timestamp":1750461001000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182004006912\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,16]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0031182004006912"],"URL":"https:\/\/doi.org\/10.1017\/s0031182004006912","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,16]]}}}