{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T22:50:45Z","timestamp":1649026245755},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T00:00:00Z","timestamp":1115164800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p><jats:italic>Strongyloides ratti<\/jats:italic>is a parasitic nematode of rats. The host immune response against<jats:italic>S. ratti<\/jats:italic>affects the development of its free-living generation, favouring the development of free-living adult males and females at the expense of directly developing, infective 3rd-stage larvae. However, how the host immune response brings about these developmental effects is not clear. To begin to investigate this, we have determined the effect of non-immune stresses on the development of<jats:italic>S. ratti<\/jats:italic>. These non-immune stresses were subcurative doses of the anthelmintic drugs Ivermectin, Dithiazanine iodide and Thiabendazole, and infection of a non-natural host, the mouse. These treatments produced the opposite developmental outcome to that of the host immune response. Thus, in infections treated with subcurative doses of Ivermectin, Dithiazanine iodide and in infections of a non-natural host, the sex ratio of developing larvae became more female-biased and the proportion of female larvae that developed into free-living adult females decreased. This suggests that the mechanism by which the host immune response and these non-immune stresses affect<jats:italic>S. ratti<\/jats:italic>development differs.<\/jats:p>","DOI":"10.1017\/s0031182005007675","type":"journal-article","created":{"date-parts":[[2005,8,16]],"date-time":"2005-08-16T10:38:50Z","timestamp":1124188730000},"page":"383-392","source":"Crossref","is-referenced-by-count":12,"title":["The effect of non-immune stresses on the development of<i>Strongyloides ratti<\/i>"],"prefix":"10.1017","volume":"131","author":[{"given":"M.","family":"CROOK","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"VINEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,5,4]]},"reference":[{"key":"S0031182005007675_ref022","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1957.02980340029008"},{"key":"S0031182005007675_ref009","unstructured":"Grove, D. I. (1989).Clinical manifestations. In Strongyloidiasis a Major Roundworm Infection of Man . (ed. Grove, D. I. ), pp.155\u2013173.Taylor & Francis,London."},{"key":"S0031182005007675_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005478"},{"key":"S0031182005007675_ref026","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1993.0148"},{"key":"S0031182005007675_ref025","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1996.0032"},{"key":"S0031182005007675_ref021","doi-asserted-by":"crossref","unstructured":"Stemmermann, G. N. and Nakasone, N. (1960). Strongyloides stercoralis infestation \u2013 malabsorption defect with reaction to dithiazanine iodide.Journal of the American Medical Association 174,104\u2013107.","DOI":"10.1001\/jama.1960.03030100018004"},{"key":"S0031182005007675_ref018","doi-asserted-by":"publisher","DOI":"10.1038\/228684a0"},{"key":"S0031182005007675_ref017","doi-asserted-by":"publisher","DOI":"10.1053\/tvjl.2000.0521"},{"key":"S0031182005007675_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182002002056"},{"key":"S0031182005007675_ref015","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1999.4413"},{"key":"S0031182005007675_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90112-5"},{"key":"S0031182005007675_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00167-3"},{"key":"S0031182005007675_ref011","doi-asserted-by":"crossref","unstructured":"Harvey, S. C. and Viney, M. E. 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