{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:04:44Z","timestamp":1759939484834},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T00:00:00Z","timestamp":1127260800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p>Our preliminary observation, that sera from schistosomiasis patients react with carcinomas, raised the possibility of antigenic cross-reactivity. We here extend this observation to show that mice experimentally infected with<jats:italic>Schistosoma mansoni<\/jats:italic>react with human urothelial and transitional bladder carcinomas and also with a gastric carcinoma cell line, AGS. To identify cross-reacting epitopes, we looked for the expression of carcinoma markers in schistosome worms and eggs using monoclonal antibodies against tumour antigens MUC1, Tn and TF (also known as the oncofetal Thomsen-Friedenreich antigen or T antigen). Immunohistochemical staining showed that the TF-epitope is present in adult intravascular<jats:italic>S. mansoni<\/jats:italic>worms and eggs deposited in tissues of infected animals. The localization of TF-immuno-reactive material in schistosomes was seen at the parasite surface between male and female worms and around trapped eggs in the liver. This localization is consistent with the antigen being secreted. Mice experimentally infected with<jats:italic>S. mansoni<\/jats:italic>, developed circulating antibodies against the TF-epitope (identified as Gal(beta1-3) GalNAc-O-R) as seen in ELISA using TF-expressing asialoglycophorin (AGP) as antigen. The observed anti-TF response in<jats:italic>S. mansoni<\/jats:italic>-infected mice reflects the complexity of host-parasite interactions in this infection.<\/jats:p>","DOI":"10.1017\/s003118200500867x","type":"journal-article","created":{"date-parts":[[2005,9,21]],"date-time":"2005-09-21T13:32:38Z","timestamp":1127309558000},"page":"73-81","source":"Crossref","is-referenced-by-count":20,"title":["Thomsen-Friedenreich oncofetal antigen in<i>Schistosoma mansoni<\/i>: localization and immunogenicity in experimental mouse infection"],"prefix":"10.1017","volume":"132","author":[{"given":"C.","family":"THORS","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"JANSSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"HELIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"LINDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,9,21]]},"reference":[{"key":"S003118200500867X_ref031","doi-asserted-by":"crossref","unstructured":"Sobin, L. H. and Wittekind, C.h. (2002). TNM Classification of Malignant Tumours ,Wiley-Liss,New York.","DOI":"10.1002\/0471463752"},{"key":"S003118200500867X_ref039","unstructured":"Zhang, S. , Zhang, H. S. , Reuter, V. E. , Slovin, S. F. , Scher, H. I. and Livingston, P. O. (1998).Expression of potential target antigens for immunotherapy on primary and metastatic prostate cancers.Clinical Cancer Research 4,295\u2013302."},{"key":"S003118200500867X_ref036","unstructured":"WORLD HEALTH ORGANIZATION (1994).Evaluation of carcinogenic risk to humans. Schistosomes, liver flukes and Helicobacter pylori .IARC Monograph 61,45\u2013119."},{"key":"S003118200500867X_ref003","unstructured":"Barranco, S. C. , Townsend, C. M. J. , Casartelli, C. , Macik, B. G. , Burger, N. L. , Boerwinkle, W. and Gourley, W. K. (1983).Establishment and characterization of an in vitro model system for human adenocarcinoma of the stomach.Cancer Research 43,1703\u20131709."},{"key":"S003118200500867X_ref035","unstructured":"van Dam, G. J. , Claas, F. H. , Yazdanbakhsh, M. , Kruize, Y. C. , van Keulen, A. C. , Ferreira, S. T. , Rotmans, J. P. and Deelder, A. M. (1996). Schistosoma mansoni excretory circulating cathodic antigen shares Lewis-x epitopes with a human granulocyte surface antigen and evokes host antibodies mediating complement-dependent lysis of granulocytes.Blood 88,4246\u20134251."},{"key":"S003118200500867X_ref034","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305101013"},{"key":"S003118200500867X_ref030","doi-asserted-by":"publisher","DOI":"10.1159\/000030056"},{"key":"S003118200500867X_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90250-9"},{"key":"S003118200500867X_ref033","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1998.00185.x"},{"key":"S003118200500867X_ref027","doi-asserted-by":"publisher","DOI":"10.1007\/s002620050316"},{"key":"S003118200500867X_ref023","unstructured":"MacLean, G. D. and Longenecker, B. M. (1991).Clinical significance of the Thomsen-Friedenreich antigen.Seminars in Cancer Biology 2,433\u2013439."},{"key":"S003118200500867X_ref021","unstructured":"Langkilde, N. C. , Wolf, H. , Clausen, H. and Orntoft, T. F. (1992).Human urinary bladder carcinoma glycoconjugates expressing T-(Gal beta(1\u20133)GalNAc alpha 1-O-R) and T-like antigens: a comparative study using peanut agglutinin and poly- and monoclonal antibodies.Cancer Research 52,5030\u20135036."},{"key":"S003118200500867X_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/11.5.395"},{"key":"S003118200500867X_ref015","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/10.2.223"},{"key":"S003118200500867X_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-4328(99)00036-0"},{"key":"S003118200500867X_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwg068"},{"key":"S003118200500867X_ref009","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970106)70:1<63::AID-IJC10>3.0.CO;2-E"},{"key":"S003118200500867X_ref001","unstructured":"Baldus, S. E. , Hanisch, F. G. , Schwonzen, M. , Nakahara, Y. , Iijima, H. , Ogawa, T. , Peter-Katalinic, J. and Uhlenbruck, G. (1992).Monoclonal antibody SP-21 defines a sialosyl-Tn antigen expressed on carcinomas and K562 erythroleukemia cells.Anticancer Research 12,1935\u20131940."},{"key":"S003118200500867X_ref011","unstructured":"Eble, J. , Sauter, G. , Epstein, J. and Sesterhenn, I. (2004) World Health Organization. Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs .IARC Press,Lyon."},{"key":"S003118200500867X_ref028","unstructured":"Samuel, J. , Noujaim, A. A. , MacLean, G. D. , Suresh, M. R. and Longenecker, B. M. (1990).Analysis of human tumor associated Thomsen-Friedenreich antigen.Cancer Research 50,4801\u20134808."},{"key":"S003118200500867X_ref002","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003400876"},{"key":"S003118200500867X_ref038","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971104)73:3<424::AID-IJC18>3.0.CO;2-C"},{"key":"S003118200500867X_ref005","doi-asserted-by":"publisher","DOI":"10.1007\/BF02484401"},{"key":"S003118200500867X_ref010","doi-asserted-by":"crossref","unstructured":"Eberl, M. , Langermans, J. A. , Vervenne, R. A. , Nyame, A. K. , Cummings, R. D. , Thomas, A. W. , Coulson, P. S. and Wilson, R. A. (2001).Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?Journal of Infectious Diseases 183,1238\u20131247.","DOI":"10.1086\/319691"},{"key":"S003118200500867X_ref022","doi-asserted-by":"publisher","DOI":"10.2307\/3283126"},{"key":"S003118200500867X_ref013","unstructured":"Hanisch, F. G. and Baldus, S. E. (1997).The Thomsen-Friedenreich (TF) antigen: a critical review on the structural, biosynthetic and histochemical aspects of a pancarcinoma-associated antigen.Histology and Histopathology 12,263\u2013281."},{"key":"S003118200500867X_ref026","doi-asserted-by":"publisher","DOI":"10.1179\/000349802125001708"},{"key":"S003118200500867X_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(99)00063-0"},{"key":"S003118200500867X_ref016","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1980.308"},{"key":"S003118200500867X_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(00)00122-4"},{"key":"S003118200500867X_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90279-9"},{"key":"S003118200500867X_ref019","unstructured":"Jurincic-Winkler, C. D. , von der Kammer, H. , Beuth, J. , Scheit, K. H. and Klippel, K. F. (1996).Antibody response to keyhole limpet hemocyanin (KLH) treatment in patients with superficial bladder carcinoma.Anticancer Research 16,2105\u20132110."},{"key":"S003118200500867X_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050656"},{"key":"S003118200500867X_ref004","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117700"},{"key":"S003118200500867X_ref020","doi-asserted-by":"publisher","DOI":"10.1042\/bj20011678"},{"key":"S003118200500867X_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4894(03)00110-3"},{"key":"S003118200500867X_ref032","doi-asserted-by":"publisher","DOI":"10.1007\/s001090050144"},{"key":"S003118200500867X_ref037","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/10.1.89"},{"key":"S003118200500867X_ref024","doi-asserted-by":"crossref","unstructured":"Mostafa, M. H. , Sheweita, S. A. and O'Connor, P. J. (1999).Relationship between schistosomiasis and bladder cancer.Clinical Microbiology Reviews 12,97\u2013111.","DOI":"10.1128\/CMR.12.1.97"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003118200500867X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T19:50:04Z","timestamp":1586461804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003118200500867X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,21]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S003118200500867X"],"URL":"https:\/\/doi.org\/10.1017\/s003118200500867x","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,21]]}}}