{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:37:23Z","timestamp":1781005043488,"version":"3.54.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T00:00:00Z","timestamp":1128556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:italic>Ascaris suum<\/jats:italic> and <jats:italic>Ascaris lumbricoides<\/jats:italic> exhibit an over-dispersed frequency distribution in their host populations in both the adult and larval stages. The impact of host factors on this observed distribution is still poorly understood and difficult to investigate in the natural host populations. The use of a mouse model has been supported by the observations that the larval migratory pattern, in this host, mimics the pattern observed in the pig. We explored the extrinsic factors that might affect the quantitative recovery of larvae during this migration in order to standardize a model system facilitating accurate future assessment of host genetic variation on this phase of the infection. In Exp. 1 larvae accumulated in the livers of both C57BL\/6j and BALB\/c mice up to and including days 4\u20135 p.i. and then declined in both strains until day 9. Loss of larvae from the livers corresponded to arrival in the lungs and maximum accumulation on day 7 p.i. but recovery was considerably higher in C57BL\/6j mice. It was concluded that day 7 recoveries gave the best indication of relative resistance\/susceptibility to this parasite. In Exp. 2 A\/J, BALB\/c, CBA\/Ca, C57BL\/6j, C3H\/HeN, DBA\/2, NIH, SJL, and SWR mice were compared. C57BL\/6j mice were identified as the most susceptible strain and CBA\/Ca mice as having the most contrasting phenotype, but with a similar kinetic pattern of migration. Finally, in Exp. 3, a strong positive correlation between the size of the inoculum and the mean worm recovery from the lungs was found in CBA\/Ca and C57BL\/6j mice, but the difference between these strains was highly consistent, 66\u00b76\u201380%, regardless of the initial dose. These results demonstrate that, using our protocols for infection and recovery, between-experiment variation in <jats:italic>A. suum<\/jats:italic> worm burdens is minimal, and that C57BL\/6j mice are highly susceptible to infection compared to other strains. The mechanistic basis of this susceptibility in relation to the resistance of other strains is unknown, but the possibilities are reviewed.<\/jats:p>","DOI":"10.1017\/s0031182005008978","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T12:46:51Z","timestamp":1128602811000},"page":"289-300","source":"Crossref","is-referenced-by-count":44,"title":["The development of a mouse model to explore resistance and susceptibility to early <i>Ascaris suum<\/i> infection"],"prefix":"10.1017","volume":"132","author":[{"given":"R.","family":"LEWIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"BEHNKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"STAFFORD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. V.","family":"HOLLAND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2005,10,6]]},"reference":[{"key":"S0031182005008978_ref016","doi-asserted-by":"crossref","unstructured":"McSharry, C. , Xia, Y. , Holland, C. V. and Kennedy, M. W. (1999).Natural immunity to Ascaris lumbricoides associated with immunoglobulin E antibody to ABA-1 allergen and inflammation indicators in children.Infection and Immunity 67,484\u2013489.","DOI":"10.1128\/IAI.67.2.484-489.1999"},{"key":"S0031182005008978_ref027","unstructured":"Slotved, H.-C. (1997).Methods for quantitative recovery of larval and adult stages of nematodes (Ascaris suum and Oesophagostomum dentatum) in pigs and mice. Ph.D. thesis. Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University,Copenhagen."},{"key":"S0031182005008978_ref021","doi-asserted-by":"crossref","unstructured":"Oksanen, A. , Eriksen, L. , Roepstorff, A. , IIsoe, B. , Nansen, P. and Lind, P. (1990).Embryonation and infectivity of Ascaris suum eggs. A comparison of eggs collected from worm uteri with eggs isolated from pig faeces.Acta Veterinaria Scandinavica 31,393\u2013398.","DOI":"10.1186\/BF03547520"},{"key":"S0031182005008978_ref025","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3135"},{"key":"S0031182005008978_ref011","doi-asserted-by":"crossref","unstructured":"Holland, C. V. and Boes, J. (2002).Distributions and predisposition: people and pigs. In The Geohelminths: Ascaris, Trichuris and Hookworm (ed. Holland, C. V. and Kennedy, M. W. ), pp.1\u201324.Kluwer Academic Publishers,Boston\/Dordrecht\/London.","DOI":"10.1007\/0-306-47383-6_1"},{"key":"S0031182005008978_ref009","unstructured":"Eriksen, L. (1981).Host-parasite relations of Ascaris suum infection in pigs and mice. Ph.D. thesis. Institute of Internal Medicine, Royal Veterinary and Agriculture University,Copenhagen."},{"key":"S0031182005008978_ref019","doi-asserted-by":"publisher","DOI":"10.2307\/3284450"},{"key":"S0031182005008978_ref008","unstructured":"Douvres, F. W. and Tromba, F. G. (1971).Comparative development of Ascaris suum in rabbits, guinea pigs, mice and swine in 11 days.Proceedings of the Helminthological Society of Washington 38,246\u2013252."},{"key":"S0031182005008978_ref022","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000006442"},{"key":"S0031182005008978_ref031","doi-asserted-by":"crossref","unstructured":"Taffs, L. F. (1965).Immunological studies on experimental infection of guinea pigs and rabbits with Ascaris suum Goeze, 1782. IV. The histopathology of the liver and lung.Journal of Helminthology 39,297\u2013302.","DOI":"10.1017\/S0022149X00020691"},{"key":"S0031182005008978_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/71641"},{"key":"S0031182005008978_ref013","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/200411189"},{"key":"S0031182005008978_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(01)48008-0"},{"key":"S0031182005008978_ref029","doi-asserted-by":"publisher","DOI":"10.2307\/3284520"},{"key":"S0031182005008978_ref023","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364030"},{"key":"S0031182005008978_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00013043"},{"key":"S0031182005008978_ref017","doi-asserted-by":"crossref","unstructured":"Mitchell, G. E. , Hogarth-Scott, R. S. , Edwards, R. D. , Lewers, H. M. , Cousins, G. and Moore, T. 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Ascaris suum larvae numbers and antiphosphorylcholine responses in infected mice of various strains and in hypothymic nu\/nu mice.International Archives of Allergy and Applied Immunity 52,64\u201378.","DOI":"10.1159\/000231669"},{"key":"S0031182005008978_ref026","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182097001480"},{"key":"S0031182005008978_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(97)00101-X"},{"key":"S0031182005008978_ref033","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082115999"},{"key":"S0031182005008978_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5769(01)00102-7"},{"key":"S0031182005008978_ref014","doi-asserted-by":"publisher","DOI":"10.1007\/BF02079221"},{"key":"S0031182005008978_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182098003382"},{"key":"S0031182005008978_ref018","doi-asserted-by":"crossref","unstructured":"Mulcahy, G. , O'Neill, S. , Fanning, J. , McCarthy, E. and Sekiya, M. (2005).Tissue migration by parasitic helminths- an immunoevasive strategy?Trends in Parasitology 21,273\u2013277.","DOI":"10.1016\/j.pt.2005.04.003"},{"key":"S0031182005008978_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01541-1"},{"key":"S0031182005008978_ref010","doi-asserted-by":"crossref","unstructured":"Eriksen, L. (1990). Ascaris suum influence of egg density and in vitro development from embyonated egg to infective egg.Acta Veterinaria Scandinavica 31,489\u2013491.","DOI":"10.1186\/BF03547532"},{"key":"S0031182005008978_ref015","doi-asserted-by":"publisher","DOI":"10.1159\/000228268"},{"key":"S0031182005008978_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(80)90023-5"},{"key":"S0031182005008978_ref032","doi-asserted-by":"publisher","DOI":"10.1007\/BF02284135"},{"key":"S0031182005008978_ref004","doi-asserted-by":"publisher","DOI":"10.1086\/315830"},{"key":"S0031182005008978_ref030","doi-asserted-by":"crossref","unstructured":"Sprent, J. F. A. and Chen, H. H. (1949).Immunological studies in mice infected with the larvae of Ascaris lumbricoides. I. Criteria of immunity and immunizing effect of isolated worm tissues.Journal of Infectious Disease 84,111\u2013124.","DOI":"10.1093\/infdis\/84.2.111"},{"key":"S0031182005008978_ref024","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.1894"},{"key":"S0031182005008978_ref012","doi-asserted-by":"publisher","DOI":"10.2307\/3279713"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182005008978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T05:56:07Z","timestamp":1750485367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182005008978\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,6]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0031182005008978"],"URL":"https:\/\/doi.org\/10.1017\/s0031182005008978","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,6]]}}}