{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:11:11Z","timestamp":1774530671600,"version":"3.50.1"},"reference-count":56,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>Fascioliasis pathogenesis depends on fluke burden. In human hyperendemic zones, individual infection intensities reach very high levels and the majority of infected subjects should be in the advanced chronic phase. The rat model offers a useful approach for pathological research in the advanced chronic period. The influence of infection intensity per rat on fluke development, pre-patent period and egg shedding (eggs\/g faeces\/worm) was analysed in 3 groups (I: 1\u20133 worms\/rat; II: 4\u20136; III: 7\u20139). Ontogenetic trajectories of fluke body measures followed a logistic model. Results showed that when the burden increases, the maximum values of fluke measures decrease. The crowding effect is manifest when fluke measures approximate their maximums in the advanced chronic stage. The pre-patent period and egg production decrease when the burden increases. This means that measurements of eggs per gramme of faeces tend to underestimate the fluke burden. The present study demonstrates how to quantify the fascioliasis experimental rat model crowding effect on adult growth, pre-patent period and egg production. This quantification may be of great interest in epidemiological studies and in experimental research on the <jats:italic>in vivo<\/jats:italic> actions of different anthelminthic drugs and vaccines, pathology, immunology and resistance studies.<\/jats:p>","DOI":"10.1017\/s003118200600059x","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T22:39:04Z","timestamp":1152139144000},"page":"453-463","source":"Crossref","is-referenced-by-count":48,"title":["Crowding effect on adult growth, pre-patent period and egg shedding of <i>Fasciola hepatica<\/i>"],"prefix":"10.1017","volume":"133","author":[{"given":"M. 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