{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T06:59:49Z","timestamp":1773730789016,"version":"3.50.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2006,7,4]],"date-time":"2006-07-04T00:00:00Z","timestamp":1151971200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>The size and fecundity of parasitic nematodes are constrained by the host immune response. For the parasitic nematode of rats,<jats:italic>Strongyloides ratti<\/jats:italic>, parasitic females infecting immunized rats are smaller and less fecund than those infecting na\u00efve rats. Here, we investigated whether these constraints on size and fecundity are life-long. This was done by comparison of worms from different immunization and immunosuppression regimes. It was found that the<jats:italic>per capita<\/jats:italic>fecundity of parasitic females of<jats:italic>S. ratti<\/jats:italic>is fully reversed, but that their size is only partially reversed, if previously immunized hosts are subsequently immunosuppressed, suggesting that fecundity is not subject to life-long constraints. The host immune response also resulted in allometric changes in the parasitic females. The significance of these results with respect to the growth and control of nematode fecundity are discussed.<\/jats:p>","DOI":"10.1017\/s003118200600062x","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T20:25:53Z","timestamp":1152131153000},"page":"477-483","source":"Crossref","is-referenced-by-count":27,"title":["The reversibility of constraints on size and fecundity in the parasitic nematode<i>Strongyloides ratti<\/i>"],"prefix":"10.1017","volume":"133","author":[{"given":"M. E.","family":"VINEY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"STEER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"WILKES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,7,4]]},"reference":[{"key":"S003118200600062X_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004005062"},{"key":"S003118200600062X_ref020","doi-asserted-by":"crossref","unstructured":"Viney, M. E. (2002).How do host immune responses affect nematode infections?Trends in Parasitology 18,63\u201366.","DOI":"10.1016\/S1471-4922(01)02171-7"},{"key":"S003118200600062X_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.03.006"},{"key":"S003118200600062X_ref015","doi-asserted-by":"publisher","DOI":"10.2307\/3545079"},{"key":"S003118200600062X_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(03)00132-6"},{"key":"S003118200600062X_ref011","doi-asserted-by":"crossref","unstructured":"Nystr\u00f6m, J. , Shen, Z-Z. , Aili, M. , Flemming, A. J. , Leroi, A. and Tuck, S. 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(2002) Experimental Design and Data Analysis for Biologists .Cambridge University Press,Cambridge.","DOI":"10.1017\/CBO9780511806384"},{"key":"S003118200600062X_ref019","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080185"},{"key":"S003118200600062X_ref017","doi-asserted-by":"crossref","unstructured":"Suzuki, Y. , Yandell, M. D. , Roy, P. J. , Krishna, S. , Savage-Dunn, C. , Ross, R. M. , Padgett, R. W. and Wood, W. B. 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