{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:21:56Z","timestamp":1760782916505},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T00:00:00Z","timestamp":1162425600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>The study was aimed at developing better orally active albendazole (ALB) formulations. Six formulations (ALB-1 to ALB-6) were prepared and tested against <jats:italic>Brugia malayi<\/jats:italic> in <jats:italic>Mastomys coucha<\/jats:italic> and jird (<jats:italic>Meriones unguiculatus<\/jats:italic>) at 200 mg\/kg, orally, for 5 consecutive days. The anti-filarial efficacy was assessed against microfilariae (mf), adult worms and female reproductive potential. Three of the 6 ALB formulations showed greatly improved female worm sterilizing potential (ALB-1: 90%; ALB-3: 63%; ALB-4: 77% of untreated control) in <jats:italic>B. malayi<\/jats:italic> \u2013 <jats:italic>M. coucha<\/jats:italic> model. Sterilization efficacy of ALB-1 was also better than that shown by pure-ALB (<jats:italic>P<\/jats:italic>&lt;0\u00b7001) or its marketed tablet formulation, Zentel (<jats:italic>P<\/jats:italic>&lt;0\u00b701), while that of ALB-4 was better than pure-ALB (<jats:italic>P<\/jats:italic>&lt;0\u00b705). The activity of ALB-3, pure-ALB and Zentel was, however, comparable. ALB-1 also showed late microfilaricidal activity with a maximum of 78% fall in microfilarial count. In contrast, neither the pure ALB nor Zentel showed any microfilaricidal activity. In the jird \u2013 <jats:italic>B. malayi<\/jats:italic> model, ALB-1 and ALB-4 showed marginal sterilizing efficacy whereas pure ALB or Zentel were ineffective. In conclusion the anti-filarial efficacy of ALB-1 was found to be superior to pure-ALB or Zentel.<\/jats:p>","DOI":"10.1017\/s0031182006001612","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T11:56:40Z","timestamp":1162468600000},"page":"537-544","source":"Crossref","is-referenced-by-count":21,"title":["Anti-filarial activity of novel formulations of albendazole against experimental brugian filariasis"],"prefix":"10.1017","volume":"134","author":[{"given":"R. L.","family":"GAUR","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"DIXIT","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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(2003).Preparation, physiochemical characterization and drug release studies of albendazole solid dispersions.Bolletino Chimico Farmaceutico 142,180\u2013186."},{"key":"S0031182006001612_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(50)90071-X"},{"key":"S0031182006001612_ref041","unstructured":"Tyagi, K. , Murthy, P. K. , Chatterjee, R. K. and Sen, A. B. (1986).Chemotherapeutic response of Brugia malayi to antifilarials in Mastomys natalensis .Indian Journal of Parasitology 10,195\u2013207."},{"key":"S0031182006001612_ref037","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70192-4"},{"key":"S0031182006001612_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90405-3"},{"key":"S0031182006001612_ref028","unstructured":"Murthy, P. K. , Tyagi, K. and Chatterjee, R. K. (1992). 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(1981).A look at the mode of action of some old and new antifilarial compounds.Annales de la Soci\u00e9t\u00e9 Belge de Medicine Tropicale 61,287\u2013296."},{"key":"S0031182006001612_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)02231-9"},{"key":"S0031182006001612_ref038","unstructured":"Tracy, J. W. and Webster, L. T. Jr. (2001).Drugs used in the chemotherapy of helminthiasis. InGoodman and Gilman's The Pharmacological Basis of Therapeutics (ed. Harman, J. G. , Limbird, L. E. and Gilman, A. G. ), 10th Edn, pp.1131\u20131133.McGraw-Hill, International Edition, New York."},{"key":"S0031182006001612_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2005.01458.x"},{"key":"S0031182006001612_ref036","unstructured":"Tanaka, H. , Takaoka, M. , Matsuda, H. and Hayashi, Y. 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