{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:28:18Z","timestamp":1791188898290,"version":"4.1.0"},"reference-count":142,"publisher":"Cambridge University Press (CUP)","issue":"S2","license":[{"start":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T00:00:00Z","timestamp":1170374400000},"content-version":"unspecified","delay-in-days":124,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>Ectoparasites of livestock are of great economic and social importance but their effective control remains difficult. The feasibility of vaccination as a novel control measure was established over a decade ago with the commercial release of a recombinant vaccine against the cattle tick<jats:italic>Boophilus microplus<\/jats:italic>. Since then, research has continued on ticks and other ectoparasites. While some ectoparasite species will undoubtedly be refractory to immunological control, for others there has been a steady accumulation of knowledge of partially protective antigens, now accelerating through the application of genomic technologies. Nevertheless, progress towards usable, commercially available vaccines has been limited by a number of factors. The number of highly effective antigens is still very small. Although some classes of antigen have been investigated in more detail than others, we have no systematic knowledge of what distinguishes an effective antigen. Much hope has been placed on the potential of multi-antigen mixtures to deliver the efficacy required of a successful vaccine but with little experimental evidence. The application of current knowledge across parasite and host species needs to be explored but little has been done. In most cases, the path to commercial delivery is uncertain. Although many constraints and challenges remain, the need for vaccines and our capacity to develop them can only increase.<\/jats:p>","DOI":"10.1017\/s0031182006001788","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T07:58:45Z","timestamp":1170489525000},"page":"S9-S25","source":"Crossref","is-referenced-by-count":46,"title":["Vaccination against ectoparasites"],"prefix":"10.1017","volume":"133","author":[{"given":"P.","family":"WILLADSEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,2,2]]},"reference":[{"key":"S0031182006001788_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-1910(98)00041-9"},{"key":"S0031182006001788_ref098","unstructured":"Sukarsih , Partoutomo, S. , Wijffels, G. and Willadsen, P. (2000 b).Vaccination trials in sheep against Chrysomya bezziana larvae using the recombinant peritrophin antigens Cb15, Cb42 and Cb48.Jurnal Ilmu Ternak Dan Veterinar, Special Edition,Vol. 5,192\u2013196."},{"key":"S0031182006001788_ref035","doi-asserted-by":"crossref","unstructured":"Francischetti, I. M. B. , Pham, V. M. , Mans, B. J. , Andersen, J. F. , Mather, T. N. , Lane, R. S. and Ribeiro, J. M. C. (2005 b).The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae).Insect Biochemistry and Molecular Biology 35,1142\u20131161.","DOI":"10.1016\/j.ibmb.2005.05.007"},{"key":"S0031182006001788_ref044","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2003.03560.x"},{"key":"S0031182006001788_ref123","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(01)00039-X"},{"key":"S0031182006001788_ref090","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(90)90044-N"},{"key":"S0031182006001788_ref100","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(99)00074-0"},{"key":"S0031182006001788_ref030","doi-asserted-by":"publisher","DOI":"10.1002\/arch.1038"},{"key":"S0031182006001788_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(98)00194-9"},{"key":"S0031182006001788_ref043","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.08.041"},{"key":"S0031182006001788_ref010","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.8.4563-4579.2003"},{"key":"S0031182006001788_ref119","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(03)00067-5"},{"key":"S0031182006001788_ref102","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(97)00197-5"},{"key":"S0031182006001788_ref124","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307529101"},{"key":"S0031182006001788_ref080","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.9657"},{"key":"S0031182006001788_ref137","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1593-1598.2001"},{"key":"S0031182006001788_ref007","unstructured":"Almaz\u00e1n, C. , Kocan, K. M. , Bergman, D. K. , Garcia-Garcia, J. C. , Blouin, E. F. and De La Fuente, J. (2003 b).Characterization of genes transcribed in an Ixodes scapularis cell line that were identified by expression library immunization and analysis of expressed sequence tags.Gene Therapy and Molecular Biology 7,43\u201359."},{"key":"S0031182006001788_ref026","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2915.1995.tb00167.x"},{"key":"S0031182006001788_ref054","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2003.09.002"},{"key":"S0031182006001788_ref122","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2004.05.005"},{"key":"S0031182006001788_ref009","unstructured":"Andreotti, R. , Sampaio, C. A. M. , Gomes, A. and Tanaka, A. S. (1999).A serine proteinase inhibitor immunoprotection from B. microplus unfed larvae in calves. IV Seminario Internacional de Parasitologia Animal, 20\u201322 October, 1999, Puerto Vallarta, Jalisco,Mexico."},{"key":"S0031182006001788_ref037","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.062904.144853"},{"key":"S0031182006001788_ref139","doi-asserted-by":"crossref","unstructured":"You, M.-J. (2005).Immunization of mice with recombinant P27\/30 protein confers protection against hard tick Haemaphysalis longicornis (Acari: Ixodidae) infestation.Journal of Veterinary Science 61,47\u201351.","DOI":"10.4142\/jvs.2005.6.1.47"},{"key":"S0031182006001788_ref031","doi-asserted-by":"crossref","unstructured":"Elvin, C. M. , Vuocolo, T. , Pearson, R. D. , East, I. J. , Riding, G. A. , Eisemann, C. H. and Tellam, R. L. (1996).Characterization of a major peritrophic membrane protein, peritrophin-44, from the larvae of Lucilia cuprina. cDNA and deduced amino acid sequences.Journal of Biological Chemistry 271,8925\u20138935.","DOI":"10.1074\/jbc.271.15.8925"},{"key":"S0031182006001788_ref028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1570-7458.1994.tb01796.x"},{"key":"S0031182006001788_ref001","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2583.2003.00416.x"},{"key":"S0031182006001788_ref083","doi-asserted-by":"crossref","unstructured":"Ribeiro, J. M. C. , Charlab, R. , Pham, V. M. , Garfield, M. and Valenzuela, J. G. (2004 a).An insight into the salivary transcriptome and proteome of the adult female mosquito Culex pipiens quinquefasciatus .Insect Biochemistry and Molecular Biology 34,543\u2013563.","DOI":"10.1016\/j.ibmb.2004.02.008"},{"key":"S0031182006001788_ref020","unstructured":"Cobon, G. S. (1997).An anti-arthropod vaccine: TickGARD \u2013 a vaccine to prevent cattle tick infestations. In New Generation Vaccines (ed. Levine, M. M. , Woodrow, G. C. , Kaper, J. B. and Cobon, G. S. ), pp.1145\u20131151.Marcel Dekker, Inc.,New York, Basel, Hong Kong."},{"key":"S0031182006001788_ref040","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/43.1.9"},{"key":"S0031182006001788_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(96)00035-5"},{"key":"S0031182006001788_ref038","unstructured":"Gough, J. M. and Kemp, D. H. (1993).Localization of a low abundance membrane protein (Bm86) on the gut cells of the cattle tick B. microplus by immunological labelling.Journal of Parasitology 79,900\u2013907."},{"key":"S0031182006001788_ref062","doi-asserted-by":"crossref","unstructured":"Mulenga, A. , Sugimoto, C. , Sako, Y. , Ohashi, K. , Musoke, A. , Mozaria, S. and Onuma, M. (1999 a).Molecular characterization of a Haemaphysalis longicornis tick salivary gland-associated 29-kilodalton protein and its effect as a vaccine against tick infestation in rabbits.Infection and Immunity 67,1652\u20131658.","DOI":"10.1128\/.67.4.1652-1658.1999"},{"key":"S0031182006001788_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2004.00463.x"},{"key":"S0031182006001788_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(96)00052-7"},{"key":"S0031182006001788_ref011","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1307.044"},{"key":"S0031182006001788_ref032","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(03)00190-0"},{"key":"S0031182006001788_ref046","unstructured":"Jonsson, N. N. , Matschoss, A. L. , Pepper, P. , Green, P. E. , Albrecht, M. S. , Hunterford, J. and Ansell, J. (2000).Evaluation of TickGARD(PLUS). a novel vaccine against B. microplus, in lactating Holstein-Friesian cows.Veterinary Parasitology 88,275\u2013285."},{"key":"S0031182006001788_ref004","doi-asserted-by":"crossref","unstructured":"Almaz\u00e1n, C. , Blas-Machado, V. , Kocan, K. M. , Yoshioka, J. H. , Blouin, E. F. , Mangold, A. J. and De La Fuente, J. (2005 a).Characterization of three Ixodes holocyclus cDNAs protective against tick infestations.Vaccine 23,4403\u20134416.","DOI":"10.1016\/j.vaccine.2005.04.012"},{"key":"S0031182006001788_ref103","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(99)00089-2"},{"key":"S0031182006001788_ref061","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.63.1063"},{"key":"S0031182006001788_ref051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2005.00571.x"},{"key":"S0031182006001788_ref120","doi-asserted-by":"crossref","unstructured":"Valenzuela, J. G. , Pham, V. M. , Garfield, M. K. , Francischetti, I. M. B. and Ribeiro, J. M. C. (2002 b).Toward a description of the sialome of the adult female mosquito Aedes aegypti .Insect Biochemistry and Molecular Biology 32,1101\u20131122.","DOI":"10.1016\/S0965-1748(02)00047-4"},{"key":"S0031182006001788_ref077","unstructured":"Pruett, J. H. , Fisher, W. F. and Temeyer, K. B. (1989).Evaluation of purified proteins of Hypoderma lineatum as candidate immunogens for a vaccine against bovine hypodermiasis.Southwestern Entomologist 14,363\u2013373."},{"key":"S0031182006001788_ref066","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2004.07.002"},{"key":"S0031182006001788_ref005","doi-asserted-by":"crossref","unstructured":"Almaz\u00e1n, C. , Kocan, K. M. , Blouin, E. F. and De La Fuente, J. (2005 b).Vaccination with recombinant tick antigens for the control of Ixodes scapularis adult infestations.Vaccine 23,5294\u20135298.","DOI":"10.1016\/j.vaccine.2005.08.004"},{"key":"S0031182006001788_ref047","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.07.036"},{"key":"S0031182006001788_ref059","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024278402288"},{"key":"S0031182006001788_ref115","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004005189"},{"key":"S0031182006001788_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.024"},{"key":"S0031182006001788_ref138","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.11.127"},{"key":"S0031182006001788_ref086","unstructured":"Riding, G. , Muharsini, S. R. I. , Pearson, R. , Sukarsih , Satria, E. , Wijffels, G. and Willadsen, P. (2000).Fractionation, identification and vaccination efficacy of native antigens from the screwworm fly, Chrysomya bezziana .Jurnal Ilmu Ternak Dan Veteriner, Special Edition, Vol. 5,150\u2013159."},{"key":"S0031182006001788_ref036","doi-asserted-by":"crossref","unstructured":"Francischetti, I. M. B. , Valenzuela, J. G. , Pham, V. M. , Garfield, M. K. and Ribeiro, J. M. C. (2002).Toward a catalog for the transcripts and proteins (sialome) from the salivary gland of the malaria vector Anopheles gambiae .Journal of Experimental Biology 205,2429\u20132451.","DOI":"10.1242\/jeb.205.16.2429"},{"key":"S0031182006001788_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2005.01.020"},{"key":"S0031182006001788_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(96)00048-3"},{"key":"S0031182006001788_ref130","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(88)90084-1"},{"key":"S0031182006001788_ref131","doi-asserted-by":"crossref","unstructured":"Willadsen, P. , Bird, P. E. , Cobon, G. S. and Hungerford, J. (1995).Commercialization of a recombinant vaccine against Boophilus microplus .Parasitology 110 (Suppl.),S43\u2013S50.","DOI":"10.1017\/S0031182000001487"},{"key":"S0031182006001788_ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.03.041"},{"key":"S0031182006001788_ref129","unstructured":"Willadsen, P. (2004).Anti-tick Vaccines in \u201cTicks, Disease and Control\u201d Parasitology (Suppl.)129,S367\u2013S388."},{"key":"S0031182006001788_ref128","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60402-9"},{"key":"S0031182006001788_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00857-X"},{"key":"S0031182006001788_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1910(92)90017-8"},{"key":"S0031182006001788_ref108","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(98)00123-4"},{"key":"S0031182006001788_ref114","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibmb.2004.10.009"},{"key":"S0031182006001788_ref069","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(00)01943-7"},{"key":"S0031182006001788_ref093","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00709.x"},{"key":"S0031182006001788_ref113","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2005.00551.x"},{"key":"S0031182006001788_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00027-9"},{"key":"S0031182006001788_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00203-X"},{"key":"S0031182006001788_ref076","unstructured":"Pruett, J. H. (2002).Immunological intervention for the control of ectoparasites of livestock \u2013 A Review.Journal of Veterinary Parasitology 16,1\u201310."},{"key":"S0031182006001788_ref106","unstructured":"Tellam, R. L. , Smith, D. , Kemp, D. H. and Willadsen, P. (1992).Vaccination against ticks. Chapter 12 In Animal Parasite Control Utilizing Biotechnology (ed. Yong W. K. ), pp.303\u2013331.CRC Press,Boca Raton."},{"key":"S0031182006001788_ref094","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.2000.0427"},{"key":"S0031182006001788_ref041","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.02.004"},{"key":"S0031182006001788_ref055","doi-asserted-by":"crossref","unstructured":"Miyoshi, T. , Tsuji, N. , Islam, K. M. , Kamio, T. and Fujisaki, K. (2004 a).Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis .Journal of Veterinary Medical Science 66,1195\u20131198.","DOI":"10.1292\/jvms.66.1195"},{"key":"S0031182006001788_ref091","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(97)00103-3"},{"key":"S0031182006001788_ref049","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004005220"},{"key":"S0031182006001788_ref050","unstructured":"Labuda, M. , Trimnell, A. R. , Lickova, M. , Kazimirova, M. , Slovak, M. and Nuttall, P. A. (2002).Recombinant tick salivary antigens (64TRP) as a TRANSBLOK vaccine against tick-borne encephalitis virus. Abstracts 4th International Conference on Ticks and Tick-Borne Pathogens,Banff,Canada p.51."},{"key":"S0031182006001788_ref052","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1991.tb00561.x"},{"key":"S0031182006001788_ref053","unstructured":"Lee, R. P. and Opdebeeck, J. P. (1991).Isolation of protective antigens from the gut of B. microplus using monoclonal antibodies.Immunology 72,121\u2013126."},{"key":"S0031182006001788_ref057","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(94)90150-3"},{"key":"S0031182006001788_ref058","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00055-2"},{"key":"S0031182006001788_ref084","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.48.060402.102812"},{"key":"S0031182006001788_ref029","unstructured":"Eisemann, C. H. , Standfast, H. A. , Tellam, R. L. , East, I. J. , Sandeman, R. M. , Arundel, J. H. and Scheurmann, E. A. (1991).Vaccination of sheep against larvae of Lucilia cuprina. Immunological control of blowfly strike, pp.76\u201381.Australian Wool Corporation, Melbourne, Australia."},{"key":"S0031182006001788_ref065","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307669100"},{"key":"S0031182006001788_ref022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1994.tb00351.x"},{"key":"S0031182006001788_ref056","doi-asserted-by":"crossref","unstructured":"Miyoshi, T. , Tsuji, N. , Islam, K. M. , Kamio, T. and Fujisaki, K. (2004 b).Cloning and molecular characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis .Insect Biochemistry and Molecular Biology 34,799\u2013808.","DOI":"10.1016\/j.ibmb.2004.04.004"},{"key":"S0031182006001788_ref070","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00095-4"},{"key":"S0031182006001788_ref121","doi-asserted-by":"publisher","DOI":"10.1007\/s10493-004-1389-6"},{"key":"S0031182006001788_ref104","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)90132-5"},{"key":"S0031182006001788_ref140","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(95)00123-9"},{"key":"S0031182006001788_ref071","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.1994.tb00151.x"},{"key":"S0031182006001788_ref081","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00043-0"},{"key":"S0031182006001788_ref079","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/35.5.861"},{"key":"S0031182006001788_ref073","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024246903197"},{"key":"S0031182006001788_ref074","doi-asserted-by":"crossref","unstructured":"Pruett, J. H. (1999 a).Immunological control of arthropod ectoparasites \u2013 a review.International Journal for Parasitology 29,25\u201332.","DOI":"10.1016\/S0020-7519(98)00172-6"},{"key":"S0031182006001788_ref075","doi-asserted-by":"crossref","unstructured":"Pruett, J. H. (1999 b).Identification and purification of a 16-kDa allergen from Psoroptes ovis (Acarina: Psoroptidae).Journal of Medical Entomology 5,544\u2013550.","DOI":"10.1093\/jmedent\/36.5.544"},{"key":"S0031182006001788_ref078","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/33.1.49"},{"key":"S0031182006001788_ref126","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009393200"},{"key":"S0031182006001788_ref087","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00173-6"},{"key":"S0031182006001788_ref134","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(88)90059-8"},{"key":"S0031182006001788_ref088","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(86)90067-6"},{"key":"S0031182006001788_ref097","doi-asserted-by":"crossref","unstructured":"Sukarsih , Partoutomo, S. , Satria, E. , Wijffels, G. , Riding, G. , Eisemann, C. and Willadsen, P. (2000 a).Vaccination against the Old World Screwworm Fly (Chrysomya bezziana).Parasite Immunology 22,545\u2013552.","DOI":"10.1046\/j.1365-3024.2000.00335.x"},{"key":"S0031182006001788_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(93)90144-N"},{"key":"S0031182006001788_ref118","doi-asserted-by":"crossref","unstructured":"Valenzuela, J. G. , Francischetti, I. M. B. , Pham, V. M. , Garfield, M. K. , Mather, T. N. and Ribeiro, J. M. C. (2002 a).Exploring the sialome of the tick Ixodes scapularis .Journal of Experimental Biology 205,2843\u20132864.","DOI":"10.1242\/jeb.205.18.2843"},{"key":"S0031182006001788_ref082","doi-asserted-by":"crossref","unstructured":"Ribeiro, J. M. C. , Andersen, J. , Silva-Neto, M. A. C. , Pham, V. M. , Garfield, M. K. and Valenzuela, J. G. (2004 b).Exploring the sialome of the blood-sucking bug Rhodnius prolixus .Insect Biochemistry and Molecular Biology 34,61\u201379.","DOI":"10.1016\/j.ibmb.2003.09.004"},{"key":"S0031182006001788_ref099","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(03)00188-2"},{"key":"S0031182006001788_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(91)90155-Z"},{"key":"S0031182006001788_ref013","doi-asserted-by":"publisher","DOI":"10.1071\/BI9880269"},{"key":"S0031182006001788_ref105","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00195-3"},{"key":"S0031182006001788_ref111","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00334-1"},{"key":"S0031182006001788_ref112","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00148-7"},{"key":"S0031182006001788_ref116","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.3.331"},{"key":"S0031182006001788_ref064","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.67.1127"},{"key":"S0031182006001788_ref117","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001486200"},{"key":"S0031182006001788_ref133","doi-asserted-by":"crossref","unstructured":"Willadsen, P. and McKenna, R. V. (1991).Vaccination with \u2018concealed\u2019 antigens: myth or reality?Parasite Immunology 13,605\u2013616.","DOI":"10.1111\/j.1365-3024.1991.tb00556.x"},{"key":"S0031182006001788_ref135","doi-asserted-by":"crossref","unstructured":"Willadsen, P. , Riding, G. A. , McKenna, R. V. , Kemp, D. H. , Tellam, R. L. , Nielsen, J. N. , Lahnstein, J. , Cobon, G. S. and Gough, J. M. (1989).Immunologic control of a parasitic arthropod. Identification of a protective antigen from B. microplus .Journal of Immunology 143,1346\u20131351.","DOI":"10.4049\/jimmunol.143.4.1346"},{"key":"S0031182006001788_ref018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.1994.tb00168.x"},{"key":"S0031182006001788_ref136","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1996.d01-90.x"},{"key":"S0031182006001788_ref141","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00073-4"},{"key":"S0031182006001788_ref142","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(97)00064-7"},{"key":"S0031182006001788_ref060","doi-asserted-by":"crossref","unstructured":"Mulenga, A. , Sugimoto, C. , Ingram, G. , Ohashi, K. and Onuma, M. (1999 b).Molecular cloning of two Haemaphysalis longicornis cathepsin L-like proteinase genes.Journal of Veterinary Medical Science 61,497\u2013502.","DOI":"10.1292\/jvms.61.497"},{"key":"S0031182006001788_ref095","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2005.00575.x"},{"key":"S0031182006001788_ref006","doi-asserted-by":"crossref","unstructured":"Almaz\u00e1n, C. , Kocan, K. M. , Bergman, D. K. , Garcia-Garcia, J. C. , Blouin, E. F. and De La Fuente, J. (2003 a).Identification of protective antigens for the control of Ixodes scapularis infestations using cDNA expression library immunization.Vaccine 21,1492\u20131501.","DOI":"10.1016\/S0264-410X(02)00683-7"},{"key":"S0031182006001788_ref132","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(93)90177-H"},{"key":"S0031182006001788_ref092","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182002002731"},{"key":"S0031182006001788_ref042","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00717.x"},{"key":"S0031182006001788_ref089","unstructured":"Sandeman, R. M. , Chandler, R. A. , Bowles, V. M. , Sandeman, R. M. , Arundel, J. H. and Scheurmann, E. A. (1991).Protease activities in blowfly larval products. Immunological control of blowfly strike, pp.98\u2013104.Australian Wool Corporation, Melbourne, Australia."},{"key":"S0031182006001788_ref016","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.17.8939"},{"key":"S0031182006001788_ref063","unstructured":"Mulenga, A. , Tsuda, C. , Sugimoto, C. and Onuma, M. (2002).Blood meal acquisition by ticks; molecular advances and implications for vaccine development.Japanese Journal of Veterinary Research 49,261\u2013272."},{"key":"S0031182006001788_ref068","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182004005633"},{"key":"S0031182006001788_ref096","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00167-1"},{"key":"S0031182006001788_ref048","doi-asserted-by":"crossref","unstructured":"Kato, N. , Iwanga, S. , Okayama, T. , Isawa, H. , Yuda, M. and Chinzei, Y. (2005).Identification and characterization of the plasma kallikrein-kinin system inhibitor, haemaphysalin, from the hard tick Haemaphysalia longicornis .Thrombosis and Haemostasis 93,359\u2013367.","DOI":"10.1160\/TH04-05-0319"},{"key":"S0031182006001788_ref072","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00203-X"},{"key":"S0031182006001788_ref109","doi-asserted-by":"publisher","DOI":"10.1603\/0022-2585-39.2.384"},{"key":"S0031182006001788_ref101","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(96)00174-9"},{"key":"S0031182006001788_ref067","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00159-5"},{"key":"S0031182006001788_ref045","doi-asserted-by":"publisher","DOI":"10.1016\/0965-1748(95)00038-W"},{"key":"S0031182006001788_ref125","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00070-3"},{"key":"S0031182006001788_ref025","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-005-1351-5"},{"key":"S0031182006001788_ref107","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-1748(02)00208-4"},{"key":"S0031182006001788_ref085","doi-asserted-by":"crossref","unstructured":"Riding, G. A. , Jarmey, J. , McKenna, R. V. , Pearson, R. , Cobon, G. S. and Willadsen, P. (1994).A protective \u201cconcealed\u201d antigen from Boophilus microplus: purification, localization and possible function.Journal of Immunology 153,5158\u20135166.","DOI":"10.4049\/jimmunol.153.11.5158"},{"key":"S0031182006001788_ref034","doi-asserted-by":"crossref","unstructured":"Francischetti, I. M. B. , Mather, T. N. and Ribeiro, J. M. C. (2005 a).Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis.Thrombosis and Haemostasis 94,167\u2013174.","DOI":"10.1160\/TH04-09-0566"},{"key":"S0031182006001788_ref127","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00042-9"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182006001788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T16:31:03Z","timestamp":1683736263000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182006001788\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":142,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0031182006001788"],"URL":"https:\/\/doi.org\/10.1017\/s0031182006001788","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}