{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:09:03Z","timestamp":1759104543742},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2006,12,11]],"date-time":"2006-12-11T00:00:00Z","timestamp":1165795200000},"content-version":"unspecified","delay-in-days":224,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:italic>Trichinella spiralis<\/jats:italic>is the nematode causative agent of trichinellosis, an intestinal and tissular parasitosis. Even though an early diagnosis during the intestinal phase is essential to limit the infection in humans, to date, there are no available tests to achieve this goal. Based on the immune response generated by the host's intestinal mucosa, the aim of this work was to develop ELISAs to assess the presence of coproantigens (CAgs), coproantibodies (CAbs) and faecal immune complexes in stool samples of 18 individuals belonging to different outbreaks that have arisen in Argentina. By the methodologies developed in this work it was found that anti-muscle larva excretory-secretory products (ML-ESP) CAbs were detected in 89% of the samples analysed regardless of the time p.i. Anti-ML-ESP IgA, IgG, IgE and IgM were detected in 56%, 56%, 28% and 22% of the individuals respectively. Those samples negative for anti-ML-ESP total immunoglobulins proved positive for anti-adult worm-ESP CAbs. No CAgs were detected in any of the samples. The results obtained in this work indicate that the intestinal immune response in human trichinellosis is featured by all the isotypes of specific immunoglobulins. Furthermore, the detection of antibodies in stool samples, in either the free or complexed form, could be applied to confirm early human trichinellosis.<\/jats:p>","DOI":"10.1017\/s0031182006001983","type":"journal-article","created":{"date-parts":[[2006,12,11]],"date-time":"2006-12-11T12:41:06Z","timestamp":1165840866000},"page":"723-727","source":"Crossref","is-referenced-by-count":6,"title":["Detection of coproantibodies and faecal immune complexes in human trichinellosis"],"prefix":"10.1017","volume":"134","author":[{"given":"G.\u00a0G.","family":"NU\u00d1EZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u00a0N.","family":"COSTANTINO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u00a0M.","family":"VENTURIELLO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2006,12,11]]},"reference":[{"key":"S0031182006001983_ref013","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.4049\/jimmunol.157.9.4037","article-title":"Intestinal transport and catabolism of IgE. A major blood-independent pathway of IgE dissemination during a Trichinella spiralis infection in rats","volume":"157","author":"Negr\u00e3o-Corr\u00eaa","year":"1996","journal-title":"Journal of Immunology"},{"key":"S0031182006001983_ref014","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00219.x"},{"key":"S0031182006001983_ref016","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2000)086[1121:IBAIAA]2.0.CO;2"},{"key":"S0031182006001983_ref002","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.4049\/jimmunol.146.10.3563","article-title":"A role for IgE in intestinal immunity. Expression of rapid expulsion of Trichinella spiralis in rats transfused with IgE and thoracic duct lymphocytes","volume":"146","author":"Ahmad","year":"1991","journal-title":"Journal of Immunology"},{"key":"S0031182006001983_ref018","first-page":"145","volume-title":"La Trichinellose: une Zoonose en \u00c9volution","author":"Soul\u00e9","year":"1991"},{"key":"S0031182006001983_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003003007"},{"key":"S0031182006001983_ref008","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1128\/JCM.32.1.190-193.1994","article-title":"Sandwich enzyme-linked immunosorbent assay for detection of excretory-secretory antigens in humans with fasciolasis","volume":"32","author":"Espino","year":"1994","journal-title":"Journal of Clinical Microbiology"},{"key":"S0031182006001983_ref001","first-page":"967","article-title":"Molecular identification of coproantigens of Cryptosporidium parvum compared to conventional staining techniques","volume":"34","author":"Abdel Baki","year":"2004","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"S0031182006001983_ref007","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1517\/14656566.3.8.1117","article-title":"Opinion on the diagnosis and treatment of human trichinellosis","volume":"3","author":"Dupouy-Camet","year":"2002","journal-title":"Expert Opinion in Pharmacotherapy"},{"key":"S0031182006001983_ref006","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/200108s2144"},{"key":"S0031182006001983_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00059-7"},{"key":"S0031182006001983_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(91)90135-B"},{"key":"S0031182006001983_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60424-8"},{"key":"S0031182006001983_ref009","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1128\/JCM.36.9.2723-2726.1998","article-title":"Dynamics of antigenemia and coproantigens during a human Fasciola hepatica outbreak","volume":"36","author":"Espino","year":"1998","journal-title":"Journal of Clinical Microbiology"},{"key":"S0031182006001983_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(83)90051-1"},{"key":"S0031182006001983_ref011","first-page":"86","article-title":"The diagnosis of human opisthorchiasis","volume":"33","author":"Jamornthanyawat","year":"2002","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"S0031182006001983_ref012","first-page":"117","volume-title":"Progress in Clinical Parasitology","author":"Murrell","year":"1994"},{"key":"S0031182006001983_ref017","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3578-8_11"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182006001983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T22:57:00Z","timestamp":1683673020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182006001983\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0031182006001983"],"URL":"https:\/\/doi.org\/10.1017\/s0031182006001983","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}