{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T01:52:00Z","timestamp":1793497920107,"version":"4.5.0"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:00:00Z","timestamp":1172102400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Cercariae of <jats:italic>Diplostomum spathaceum<\/jats:italic> penetrate the skin of fish, and then migrate along blood vessels and tissues towards the head and the eye-lens. We studied their orientation behaviour in tail fins of guppies and in chemical concentration gradients within agar-filled choice chambers. In fins, they entered veins and orientated cranially, independent of the blood flow and living cells. In choice chambers, they were attracted by a small molecular fraction of fish serum, D-glucose (at 1, 10, and 1000\u00a0\u03bc<jats:sc>m<\/jats:sc>), D-mannose, D-maltotriose and Cl-ions, whereas D-glucosamine repelled them (even at 1\u00b70\u00a0n<jats:sc>m<\/jats:sc>). Amino acids were not attractive, but arginine in tetrapeptides attracted at concentrations as low as 1\u00a0\u03bc<jats:sc>m<\/jats:sc> and melatonin at 0\u00b74\u20134\u00b73\u00a0p<jats:sc>m<\/jats:sc>. We suggest a preliminary model for the behaviour of diplostomula in fish fins and attracting (+) or repelling (\u2212) host cues: (1) migration towards deeper skin layers and avoidance of skin surface, cues: Cl-ions (+ and \u2212), glucose (+), glucosamine (\u2212), light radiation (\u2212); (2) orientation in cranial direction, cue: Cl-ions (+); (3) localization of blood vessels, cues: glucose (+), arginine-residues (+); (4) localization of the retina, cue: melatonin (+). A comparison with the navigation mechanisms of tissue-migrating schistosomules and hookworm larvae reveals an enormous diversity of strategies.<\/jats:p>","DOI":"10.1017\/s0031182007002430","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T15:08:05Z","timestamp":1172156885000},"page":"1013-1023","source":"Crossref","is-referenced-by-count":28,"title":["Navigation within host tissues: cues for orientation of <i>Diplostomum spathaceum<\/i> (Trematoda) in fish towards veins, head and eye"],"prefix":"10.1017","volume":"134","author":[{"given":"W.","family":"HAAS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"WULFF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"GRABE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"MEYER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"HAEBERLEIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,2,22]]},"reference":[{"key":"S0031182007002430_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200004614X"},{"key":"S0031182007002430_ref032","doi-asserted-by":"publisher","DOI":"10.1007\/BF02185515"},{"key":"S0031182007002430_ref006","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.00993.x"},{"key":"S0031182007002430_ref023","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-004-1257-7"},{"key":"S0031182007002430_ref041","doi-asserted-by":"publisher","DOI":"10.1139\/z03-212"},{"key":"S0031182007002430_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000063897"},{"key":"S0031182007002430_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(78)90301-8"},{"key":"S0031182007002430_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00089-9"},{"key":"S0031182007002430_ref034","doi-asserted-by":"publisher","DOI":"10.1002\/jez.a.10309"},{"key":"S0031182007002430_ref005","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00050.2003"},{"key":"S0031182007002430_ref028","doi-asserted-by":"publisher","DOI":"10.1007\/BF00004303"},{"key":"S0031182007002430_ref008","doi-asserted-by":"publisher","DOI":"10.4319\/lo.1999.44.8.1904"},{"key":"S0031182007002430_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(74)90088-5"},{"key":"S0031182007002430_ref024","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2095.2002.00200.x"},{"key":"S0031182007002430_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182001001032"},{"key":"S0031182007002430_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00334-4"},{"key":"S0031182007002430_ref030","first-page":"143","article-title":"Glucose intolerance in teleost fish: fact or fiction","volume":"129B","author":"Moon","year":"2001","journal-title":"Comparative Biochemistry and Physiology"},{"key":"S0031182007002430_ref026","first-page":"157","volume-title":"The Physiology of Fishes","author":"Karnaky","year":"1998"},{"key":"S0031182007002430_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-003-1045-9"},{"key":"S0031182007002430_ref003","doi-asserted-by":"publisher","DOI":"10.2307\/3271858"},{"key":"S0031182007002430_ref029","doi-asserted-by":"publisher","DOI":"10.1002\/jez.10127"},{"key":"S0031182007002430_ref042","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2003.02111.x"},{"key":"S0031182007002430_ref018","first-page":"197","volume-title":"Advances in Trematode Biology","author":"Haas","year":"1997"},{"key":"S0031182007002430_ref002","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014084313207"},{"key":"S0031182007002430_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000021284"},{"key":"S0031182007002430_ref007","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400930304"},{"key":"S0031182007002430_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0981(99)00169-0"},{"key":"S0031182007002430_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2004.04.012"},{"key":"S0031182007002430_ref012","first-page":"741","article-title":"Haematology and clinical chemistry of cyprinid fish. 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