{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:42:33Z","timestamp":1791258153449,"version":"4.1.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>For thousands of years the deadliest human parasite,<jats:italic>Plasmodium falciparum<\/jats:italic>, has been evolving in populations also infected by the most prevalent parasites, worms. This is likely to have shaped the genome of all 3 protagonists\u00a0\u2013\u00a0man, worms and malaria. Observational studies in Thailand have shown that although<jats:italic>P<\/jats:italic>.<jats:italic>falciparum<\/jats:italic>malaria incidence increased two-fold in helminth-infected patients, there was a 64% reduction of cerebral malaria and an 84% reduction of acute renal failure in helminth-infected patients relative to those without helminths. In addition, it was suggested that mixed infections, anaemia and gametocyte carriage were more frequent in helminth-infected patients. On the contrary, fever was lower in helminth-infected patients. The present hypotheses, their implications and the limitations of the results described and of those from studies in Africa are discussed.<\/jats:p>","DOI":"10.1017\/s0031182008000358","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T10:01:35Z","timestamp":1207044095000},"page":"861-868","source":"Crossref","is-referenced-by-count":35,"title":["Worms and malaria: blind men feeling the 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