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Whilst most of the common laboratory strains of mice are permissive hosts for the parasite, in this study we report for the first time, the strong resistance of na\u00efve FVB\/N mice to<jats:italic>N. brasiliensis<\/jats:italic>. Damage to larvae is evident within the first 24 h of infection and this may be critical to later larval development and reproductive success. Inflammatory responses in the skin, and larval escape from this tissue were comparable in susceptible CBA\/Ca and resistant FVB\/N mice, with most larvae exiting within 4 h of a primary infection. Lung larval burdens were also similar between strains, but larvae recovered from FVB\/N mice were smaller and less motile. In FVB\/N mice, larval colonization of the gut was impaired and worms produced very few eggs. However FVB\/N mice did not show enhanced resistance to<jats:italic>Heligmosomoides bakeri<\/jats:italic>(also known as<jats:italic>Heligmosomoides polygyrus<\/jats:italic>), a nematode largely restricted to the gut. Damage done in the pre-lung or lung stages of infection with<jats:italic>N. brasiliensis<\/jats:italic>is likely to contribute to ongoing developmental and functional abnormalities, which are profoundly evident in the gut phase of infection.<\/jats:p>","DOI":"10.1017\/s0031182008005192","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T11:57:00Z","timestamp":1231329420000},"page":"93-106","source":"Crossref","is-referenced-by-count":13,"title":["FVB\/N mice are highly resistant to primary infection with<i>Nippostrongylus brasiliensis<\/i>"],"prefix":"10.1017","volume":"136","author":[{"given":"M. L.","family":"KNOTT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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