{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:03:36Z","timestamp":1649192616399},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T00:00:00Z","timestamp":1232496000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Mice fed 1\u00b75 mg ochratoxin A (OTA) per kg body weight and infected with <jats:italic>Trypanosoma brucei rhodesiense<\/jats:italic> were compared with trypanosome-infected placebo-fed and uninfected OTA-fed controls. Uninfected OTA-fed mice showed fever, lethargy, facial and eyelid oedemas, mild hepatitis and nephritis, and high survival. Infected placebo-fed controls had mean pre-patent period (PPP) of 3\u00b726 days, lethargy, dyspnoea, fever, facial and scrotal oedema, survival of 33\u201365 days, reduced red cell counts (RCC: 10\u00b796\u20136\u00b787\u00d710<jats:sup>6<\/jats:sup> cells\/\u03bcl of blood), packed cell volume (PCV: 43\u00b719\u201326\u00b736%), haemoglobin levels (Hb: 13\u00b737\u20137\u00b792 g\/dL) and mean corpuscular volume (MCV) of 37\u00b796\u201341\u00b731 fL, hepatosplenomegaly, generalized oedemas, heart congestion, hepatitis and nephritis. Compared to infected placebo-fed controls, infected OTA-fed mice had significantly (<jats:italic>P<\/jats:italic>&lt;0\u00b705) shorter mean PPP (2\u00b758 days), reduced survival (6\u201347 days), more pronounced fever and dyspnoea. The latter had significantly (<jats:italic>P<\/jats:italic>&lt;0\u00b705) reduced RCC (10\u00b774\u20134\u00b756\u00d710<jats:sup>6<\/jats:sup> cells\/\u03bcl of blood), PCV (43\u00b790\u201320\u00b778%), Hb (13\u00b706\u20135\u00b774 g\/dL), increased MCV (39\u00b710\u201343\u00b797 fL), severe generalized oedemas, haemorrhages, congestion, hepatic haemosiderosis, hepatitis, nephritis, endocarditis, pericarditis and exclusively, splenic macrophage and giant cell hyperplasia, expanded red pulp and splenic erythrophagocytosis. It was concluded that OTA aggravated the pathogenesis of <jats:italic>T. b. rhodesiense<\/jats:italic> infection in mice, and should therefore be taken into consideration during trypanosomosis control programmes.<\/jats:p>","DOI":"10.1017\/s0031182008005386","type":"journal-article","created":{"date-parts":[[2009,1,21]],"date-time":"2009-01-21T04:57:17Z","timestamp":1232513837000},"page":"273-281","source":"Crossref","is-referenced-by-count":3,"title":["Aggravation of pathogenesis mediated by ochratoxin A in mice infected with <i>Trypanosoma brucei rhodesiense<\/i>"],"prefix":"10.1017","volume":"136","author":[{"given":"J. K.","family":"KIBUGU","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J. N.","family":"NGERANWA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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