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Ultrastructural changes to the flukes were assessed using transmission electron microscopy (TEM), with a view to gathering information on the mechanism(s) of action for compound alpha and on the possible route of its entry into <jats:italic>F. hepatica<\/jats:italic>. The tegumental syncytium was more severely affected than the gut at all time-points p.t. with compound alpha, suggesting a predominantly trans-tegumental route of uptake. Disruption to the tegumental system became increasingly severe over time. A stress response was observed at 24 h p.t. and took the form of blebbing and increases in the production and transport of secretory bodies. By 72 h p.t., extensive tegumental loss and degeneration of the tegumental cell bodies had occurred. Degeneration of subtegumental tissues and internal flooding were also observed. Changes in the gastrodermal cells were slow to develop: reduced secretory activity was evident at 72 h p.t.. There was progressive disruption to the somatic muscle layers, with disorganization of the muscle blocks and loss of muscle fibres.<\/jats:p>","DOI":"10.1017\/s0031182009005678","type":"journal-article","created":{"date-parts":[[2009,4,16]],"date-time":"2009-04-16T04:25:55Z","timestamp":1239855955000},"page":"665-680","source":"Crossref","is-referenced-by-count":19,"title":["Ultrastructural changes to the tegumental system and the gastrodermal cells in adult <i>Fasciola hepatica<\/i> following <i>in vivo<\/i> treatment with the experimental fasciolicide, compound alpha"],"prefix":"10.1017","volume":"136","author":[{"given":"M.","family":"McCONVILLE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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