{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:23:10Z","timestamp":1759530190226,"version":"3.37.0"},"reference-count":57,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T00:00:00Z","timestamp":1245024000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Changes in the cardiac \u03b2-adrenergic system in early stages of<jats:italic>Trypanosoma cruzi<\/jats:italic>infection have been described. Here, we studied an early (135 days post-infection\u2013p.i.) and a late stage (365 days p.i.) of the cardiac chronic form of the experimental infection (Tulahuen or SGO-Z12 strains), determining plasma epinephrine and norepinephrine levels, \u03b2-receptor density, affinity and function, cardiac cAMP concentration and phosphodiesterase activity, cardiac contractility, and the presence of \u03b2-receptor autoantibodies. Tulahuen-infected mice presented lower epinephrine and norepinephrine levels; lower \u03b2-receptor affinity and density; a diminished norepinephrine response and higher cAMP levels in the early stage, and a basal contractility similar to non-infected controls in the early and augmented in the late stage. The Tulahuen strain induced autoantibodies with weak \u03b2-receptor interaction. SGO-Z12-infected mice presented lower norepinephrine levels and epinephrine levels that diminished with the evolution of the infection; lower \u03b2-receptor affinity and an increased density; unchanged epinephrine and norepinephrine response in the early and a diminished response in the late stage; higher cAMP levels and unchanged basal contractility. The SGO-Z12 isolate induced \u03b2-receptor autoantibodies with strong interaction with the \u03b2-receptors. None of the antibodies, however, acted a as \u03b2-receptor agonist. The present results demonstrate that this system is seriously compromised in the cardiac chronic stage of<jats:italic>T. cruzi<\/jats:italic>infection.<\/jats:p>","DOI":"10.1017\/s0031182009006337","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T08:23:26Z","timestamp":1245054206000},"page":"905-918","source":"Crossref","is-referenced-by-count":6,"title":["Involvement of the \u03b2-adrenergic system in the cardiac chronic form of experimental<i>Trypanosoma cruzi<\/i>infection"],"prefix":"10.1017","volume":"136","author":[{"given":"M. S.","family":"LO PRESTI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"RIVAROLA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"FERN\u00c1NDEZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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