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Investigations in the 1970s\u20131980s on the fate of the rat tapeworm,<jats:italic>Hymenolepis diminuta<\/jats:italic>, in rats and mice and the systemic and local responses evoked following infection have contributed directly to our knowledge of how permissive and non-permissive hosts respond to the challenge of infection with a helminth parasite. This convenient laboratory model system has, in the authors' opinion, regrettably received considerably less attention in recent years. With the goal of highlighting the utility of this model system, data is presented on: (1) the immune and enteric responses of rats and mice to infection with<jats:italic>H. diminuta<\/jats:italic>; (2) the ability of excretory or secretory products derived from<jats:italic>H. diminuta<\/jats:italic>to significantly reduce T cell and macrophage activation<jats:italic>in vitro<\/jats:italic>; and (3) how assessment of<jats:italic>H. diminuta<\/jats:italic>-rodent models can be used to identify immune effector or regulatory mechanisms that can be translated into novel treatments for inflammatory and autoimmune disorders.<\/jats:p>","DOI":"10.1017\/s0031182009990886","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T09:48:43Z","timestamp":1250761723000},"page":"385-394","source":"Crossref","is-referenced-by-count":47,"title":["The immune response to and immunomodulation by<i>Hymenolepis diminuta<\/i>"],"prefix":"10.1017","volume":"137","author":[{"given":"DEREK M.","family":"McKAY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,8,20]]},"reference":[{"key":"S0031182009990886_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044279"},{"key":"S0031182009990886_ref043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2007.00973.x"},{"key":"S0031182009990886_ref004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"S0031182009990886_ref046","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-541-1_24"},{"key":"S0031182009990886_ref055","doi-asserted-by":"publisher","DOI":"10.1159\/000139836"},{"key":"S0031182009990886_ref051","first-page":"48122","article-title":"A novel host-parasite lipid cross-talk","volume":"277","author":"van der Kleij","year":"2002","journal-title":"Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. 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