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In the present study, we investigated the effectiveness of Kp against visceral leishmaniasis, using the BALB\/c mouse model of infection with <jats:italic>Leishmania chagasi<\/jats:italic>. Mice receiving oral daily doses of Kp (400 mg\/kg) for 30 days displayed significantly reduced hepatic and splenic parasite burden, when compared with untreated animals. Protectiveness was accompanied by a reduction in parasite-specific IgG serum levels, and impaired capacity of spleen cells to produce IL-4, but not IFN-\u03b3 and nitric oxide upon antigen recall <jats:italic>in vitro<\/jats:italic>. The reference drug Pentostam (72 mg\/kg) given by the intra-peritoneal route on alternate days produced an anti-leishmanial effect similar to oral Kp. Our findings show that the oral efficacy of Kp, seen previously in murine cutaneous leishmaniasis, extends also to visceral leishmaniasis caused by <jats:italic>L. chagasi<\/jats:italic>, a difficult to treat and lethal disease of man.<\/jats:p>","DOI":"10.1017\/s0031182009991405","type":"journal-article","created":{"date-parts":[[2009,12,7]],"date-time":"2009-12-07T14:08:09Z","timestamp":1260194889000},"page":"613-618","source":"Crossref","is-referenced-by-count":32,"title":["Effectiveness of the immunomodulatory extract of <i>Kalanchoe pinnata<\/i> against murine visceral leishmaniasis"],"prefix":"10.1017","volume":"137","author":[{"given":"D. C. O.","family":"GOMES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"MUZITANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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