{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:29:02Z","timestamp":1791044942610,"version":"4.1.0"},"reference-count":108,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,12,7]],"date-time":"2009-12-07T00:00:00Z","timestamp":1260144000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>As more facts emerge regarding the ways in which<jats:italic>E. multilocularis<\/jats:italic>-derived molecules trigger the host immune response and modulate the host-parasite interplay, it becomes possible to envisage how the parasite can survive and proliferate in its intermediate host, while in other hosts it dies out. Through effects on cells of both the innate and adaptive arms of the immune response,<jats:italic>E. multilocularis<\/jats:italic>can orchestrate a range of outcomes that are beneficial not only to the parasite, in terms of facilitating its intrahepatic proliferation and maturation, and thus life cycle over all, but also to its intermediate host, in limiting pathology. The present review deals with the role of metacestode surface molecules as well as excretory\/secretory (E\/S) metabolic products of the parasite in the modulation of the host responses such as to optimize its own survival.<\/jats:p>","DOI":"10.1017\/s0031182009991533","type":"journal-article","created":{"date-parts":[[2009,12,7]],"date-time":"2009-12-07T14:29:40Z","timestamp":1260196180000},"page":"557-568","source":"Crossref","is-referenced-by-count":33,"title":["Triggering and modulation of the host-parasite interplay by<i>Echinococcus multilocularis<\/i>: a review"],"prefix":"10.1017","volume":"137","author":[{"given":"N.","family":"MEJRI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"HEMPHILL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"GOTTSTEIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,12,7]]},"reference":[{"key":"S0031182009991533_ref109","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-004-3134-9"},{"key":"S0031182009991533_ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.10.006"},{"key":"S0031182009991533_ref106","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1737"},{"key":"S0031182009991533_ref105","doi-asserted-by":"publisher","DOI":"10.2741\/1770"},{"key":"S0031182009991533_ref104","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6453"},{"key":"S0031182009991533_ref099","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90162-4"},{"key":"S0031182009991533_ref097","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.21.120601.141126"},{"key":"S0031182009991533_ref095","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.05.008"},{"key":"S0031182009991533_ref094","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.01.016"},{"key":"S0031182009991533_ref091","first-page":"281","article-title":"Stage-specific expression of the 14-3-3 gene in Echinococcus multilocularis","volume":"91","author":"Siles Lucas","year":"1998","journal-title":"Molecular and Biochemical Parasitology"},{"key":"S0031182009991533_ref089","doi-asserted-by":"publisher","DOI":"10.7883\/yoken1952.47.65"},{"key":"S0031182009991533_ref088","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/0973-029X.40933","article-title":"Eosinophils in health and disease","volume":"7","author":"Saraswathi","year":"2003","journal-title":"Journal of Oral Maxillofacial Pathology"},{"key":"S0031182009991533_ref087","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2007.04.016"},{"key":"S0031182009991533_ref086","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70364-0"},{"key":"S0031182009991533_ref082","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000055864"},{"key":"S0031182009991533_ref081","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00682.x"},{"key":"S0031182009991533_ref079","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)80066-1"},{"key":"S0031182009991533_ref078","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(92)90056-Q"},{"key":"S0031182009991533_ref077","first-page":"113","article-title":"Immune response to Echinococcus multilocularis infection in the mouse model","volume":"40","author":"Playford","year":"1992","journal-title":"Japanese Journal of Veterinary Research"},{"key":"S0031182009991533_ref076","first-page":"128","article-title":"The mast cell and gut nematodes: damage and defence","volume":"90","author":"Pennock","year":"2006","journal-title":"Chemical Immunology and Allergy"},{"key":"S0031182009991533_ref075","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1128\/IAI.64.9.3682-3687.1996","article-title":"Inhibition of human peripheral blood mononuclear cell proliferative response by glycosphingolipids from metacestodes of Echinococcus multilocularis","volume":"64","author":"Persat","year":"1996","journal-title":"Infection and Immunity"},{"key":"S0031182009991533_ref074","doi-asserted-by":"crossref","first-page":"8764","DOI":"10.1016\/S0021-9258(19)50344-1","article-title":"Glycosphingolipids with Gal beta 1\u20136Gal sequences in metacestodes of the parasite Echinococcus multilocularis","volume":"267","author":"Persat","year":"1992","journal-title":"Journal of Biological Chemistry"},{"key":"S0031182009991533_ref073","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761997000800013"},{"key":"S0031182009991533_ref072","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80533-6"},{"key":"S0031182009991533_ref071","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(89)90187-4"},{"key":"S0031182009991533_ref070","doi-asserted-by":"publisher","DOI":"10.1038\/nri2132"},{"key":"S0031182009991533_ref068","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-009-1549-z"},{"key":"S0031182009991533_ref066","doi-asserted-by":"publisher","DOI":"10.2307\/3283349"},{"key":"S0031182009991533_ref065","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00191.x"},{"key":"S0031182009991533_ref055","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.4049\/jimmunol.147.5.1659","article-title":"Immune suppression induced by protoscoleces of Echinococcus multilocularis in mice. Evidence for the presence of CD8dull suppressor cells in spleens of mice intraperitoneally infected with E. multilocularis","volume":"147","author":"Kizaki","year":"1991","journal-title":"Journal of Immunology"},{"key":"S0031182009991533_ref051","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00374.x"},{"key":"S0031182009991533_ref049","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.52.41"},{"key":"S0031182009991533_ref045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03142.x"},{"key":"S0031182009991533_ref040","doi-asserted-by":"publisher","DOI":"10.1038\/85321"},{"key":"S0031182009991533_ref039","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.03.002"},{"key":"S0031182009991533_ref038","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0659-7"},{"key":"S0031182009991533_ref037","doi-asserted-by":"publisher","DOI":"10.3201\/eid0703.017307"},{"key":"S0031182009991533_ref044","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"S0031182009991533_ref036","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0659-7"},{"key":"S0031182009991533_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00273-7"},{"key":"S0031182009991533_ref033","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01308.x"},{"key":"S0031182009991533_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90336-0"},{"key":"S0031182009991533_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(91)90108-I"},{"key":"S0031182009991533_ref028","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1005547"},{"key":"S0031182009991533_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00243-6"},{"key":"S0031182009991533_ref026","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00280.x"},{"key":"S0031182009991533_ref018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01885.x"},{"key":"S0031182009991533_ref015","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1999.00723.x"},{"key":"S0031182009991533_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-003-0394-2"},{"key":"S0031182009991533_ref008","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021908"},{"key":"S0031182009991533_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2005.09.001"},{"key":"S0031182009991533_ref006","first-page":"1","article-title":"MIC genes: from genetics to biology","volume":"76","author":"Bahram","year":"2000","journal-title":"Advances in Immunology"},{"key":"S0031182009991533_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.003"},{"key":"S0031182009991533_ref083","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1128\/IAI.67.12.6461-6472.1999","article-title":"Regulation of human CD4(+) alpha-beta T-cell-receptor-positive (TCR(+)) and gamma-delta TCR(+) T-cell responses to Mycobacterium tuberculosis by interleukin-10 and transforming growth factor beta","volume":"67","author":"Rojas","year":"1999","journal-title":"Infection and Immunity"},{"key":"S0031182009991533_ref030","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.7.3969-3972.2002"},{"key":"S0031182009991533_ref101","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.1.527-536.2004"},{"key":"S0031182009991533_ref058","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.09.023"},{"key":"S0031182009991533_ref023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1996.tb01030.x"},{"key":"S0031182009991533_ref019","first-page":"15","article-title":"Intraperitoneal murine alveolar hydatidosis: relationship between the size of the larval cyst mass, immigrant inflammatory cells, splenomegaly and thymus involution","volume":"34","author":"Devouge","year":"1983","journal-title":"Tropenmedizin und Parasitologie"},{"key":"S0031182009991533_ref034","first-page":"401","article-title":"Increased basal production of interleukin-10 by peripheral blood mononuclear cells in human alveolar echinococcosis","volume":"8","author":"Godot","year":"1997","journal-title":"European Cytokine Network"},{"key":"S0031182009991533_ref061","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1998053231"},{"key":"S0031182009991533_ref013","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0730640100"},{"key":"S0031182009991533_ref060","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.7.3350-3352.2004"},{"key":"S0031182009991533_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0176-6724(88)80026-9"},{"key":"S0031182009991533_ref084","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0503226"},{"key":"S0031182009991533_ref093","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(02)00517-0"},{"key":"S0031182009991533_ref025","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051615"},{"key":"S0031182009991533_ref059","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2009.02.019"},{"key":"S0031182009991533_ref103","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(99)00027-3"},{"key":"S0031182009991533_ref054","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1998.0432"},{"key":"S0031182009991533_ref041","doi-asserted-by":"publisher","DOI":"10.1038\/39614"},{"key":"S0031182009991533_ref020","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.12.6891"},{"key":"S0031182009991533_ref048","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00177-0"},{"key":"S0031182009991533_ref022","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1998.00131.x"},{"key":"S0031182009991533_ref056","first-page":"412","article-title":"Generation of CD8+ suppressor T cells by protoscoleces of Echinococcus multilocularis in vitro","volume":"79","author":"Kizaki","year":"1993","journal-title":"Immunology"},{"key":"S0031182009991533_ref042","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21382"},{"key":"S0031182009991533_ref047","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182098002406"},{"key":"S0031182009991533_ref017","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01567.x"},{"key":"S0031182009991533_ref062","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.2116"},{"key":"S0031182009991533_ref067","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00836.x"},{"key":"S0031182009991533_ref046","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107161200"},{"key":"S0031182009991533_ref102","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.6.889"},{"key":"S0031182009991533_ref050","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000061321"},{"key":"S0031182009991533_ref032","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050463"},{"key":"S0031182009991533_ref098","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5837"},{"key":"S0031182009991533_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1990.tb05457.x"},{"key":"S0031182009991533_ref014","first-page":"16","article-title":"Activation of normal murine B cells by Echinococcus granulosus","volume":"67","author":"Cox","year":"1989","journal-title":"Immunology"},{"key":"S0031182009991533_ref090","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(03)00072-4"},{"key":"S0031182009991533_ref024","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260528"},{"key":"S0031182009991533_ref052","doi-asserted-by":"publisher","DOI":"10.1086\/516316"},{"key":"S0031182009991533_ref085","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3920"},{"key":"S0031182009991533_ref108","doi-asserted-by":"publisher","DOI":"10.1086\/586709"},{"key":"S0031182009991533_ref021","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00243.x"},{"key":"S0031182009991533_ref063","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1982"},{"key":"S0031182009991533_ref002","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1999.00245.x"},{"key":"S0031182009991533_ref096","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1128\/IAI.63.5.1688-1697.1995","article-title":"Interleukin-5 is the predominant cytokine produced by peripheral blood \u2013 mononuclear cells in alveolar echinococcosis","volume":"63","author":"Sturm","year":"1995","journal-title":"Infection and Immunity"},{"key":"S0031182009991533_ref069","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6560"},{"key":"S0031182009991533_ref016","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.10.6074-6083.2001"},{"key":"S0031182009991533_ref092","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2003.10.003"},{"key":"S0031182009991533_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90073-5"},{"key":"S0031182009991533_ref057","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.04.006"},{"key":"S0031182009991533_ref064","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.6.3892"},{"key":"S0031182009991533_ref053","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.026"},{"key":"S0031182009991533_ref100","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00230-9"},{"key":"S0031182009991533_ref043","doi-asserted-by":"publisher","DOI":"10.1038\/nri1741"},{"key":"S0031182009991533_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0"},{"key":"S0031182009991533_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2004.03.002"},{"key":"S0031182009991533_ref005","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00724.x"}],"updated-by":[{"DOI":"10.1017\/s003118201600086x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000}}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182009991533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T20:09:49Z","timestamp":1685218189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182009991533\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,7]]},"references-count":108,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0031182009991533"],"URL":"https:\/\/doi.org\/10.1017\/s0031182009991533","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,7]]}}}