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While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology.<\/jats:p>","DOI":"10.1017\/s0031182010000223","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T09:06:29Z","timestamp":1273050389000},"page":"2017-2027","source":"Crossref","is-referenced-by-count":45,"title":["Current status of vaccination against African trypanosomiasis"],"prefix":"10.1017","volume":"137","author":[{"given":"STEFAN","family":"MAGEZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GUY","family":"CALJON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"THAO","family":"TRAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BENO\u00ceT","family":"STIJLEMANS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAGDALENA","family":"RADWANSKA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,5,5]]},"reference":[{"key":"S0031182010000223_ref097","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1128\/IAI.61.11.4540-4545.1993","article-title":"Organization of two invariant surface glycoproteins in the surface coat of Trypanosoma brucei","volume":"61","author":"Ziegelbauer","year":"1993","journal-title":"Infection and Immunity"},{"key":"S0031182010000223_ref041","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.4049\/jimmunol.160.4.1949","article-title":"The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors","volume":"160","author":"Magez","year":"1998","journal-title":"Journal of Immunology"},{"key":"S0031182010000223_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(98)00014-0"},{"key":"S0031182010000223_ref054","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.11.1563"},{"key":"S0031182010000223_ref071","doi-asserted-by":"publisher","DOI":"10.1038\/352731a0"},{"key":"S0031182010000223_ref085","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2008.04.012"},{"key":"S0031182010000223_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.02.032"},{"key":"S0031182010000223_ref093","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.4049\/jimmunol.143.4.1346","article-title":"Immunologic control of a parasitic arthropod. 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