{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:51:01Z","timestamp":1761929461874},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T00:00:00Z","timestamp":1274832000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p><jats:bold>Objective.<\/jats:bold>Bilharziosis is one of the most important helminthal infections in humans and is caused by blood flukes of the genus<jats:italic>Schistosoma.<\/jats:italic>Three different life stages of the parasite occur within the mammalian host: schistosomula located in the skin, pre-adults located in the lung and adult worms located in the portal venous system. Erythrocytes are a major source of nutrient supply for adults. However, sources of nutrition for the developing stages are still unclear.<jats:bold>Methods.<\/jats:bold>To investigate whether schistosomula, pre-adults and adults of<jats:italic>Schistosoma mansoni<\/jats:italic>ingest human serum albumin (HSA)<jats:italic>in vitro<\/jats:italic>, these life stages were incubated with aminofluorescein-labelled human serum albumin (Afl-HSA) for 5 h. To test the uptake of albumin<jats:italic>in vivo<\/jats:italic>, the albumin conjugate was given intravenously to<jats:italic>S. mansoni<\/jats:italic>infected NMRI mice 24 h before harvesting the 3 life stages.<jats:bold>Results.<\/jats:bold>In comparison to the control group schistosomula, pre-adults, and adults showed an accumulation of Afl-HSA within the oesophagus and intestinal caecum<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>.<jats:bold>Conclusion.<\/jats:bold>Our findings suggest that albumin seems to be a major source of energy supply for the early schistosomal life stages and an additive energy support for adult worms. Since albumin has been used successfully as a drug carrier for chemotherapeutic substances against malignant disorders, further studies will focus on albumin as a carrier for anthelminthics in a drug-targeting model.<\/jats:p>","DOI":"10.1017\/s0031182010000405","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T08:40:01Z","timestamp":1274863201000},"page":"1645-1652","source":"Crossref","is-referenced-by-count":14,"title":["Schistosomula, pre-adults and adults of<i>Schistosoma mansoni<\/i>ingest fluorescence-labelled albumin<i>in vitro<\/i>and<i>in vivo<\/i>: implication for a drug-targeting model"],"prefix":"10.1017","volume":"137","author":[{"given":"M. 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