{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:53:16Z","timestamp":1784357596949,"version":"3.55.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T00:00:00Z","timestamp":1277078400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Intestinal schistosomiasis continues to be a major public health problem in sub-Saharan Africa, and is endemic in communities around Lake Victoria. Interest is growing in the molecular evolution and population genetic structure of<jats:italic>Schistosoma mansoni<\/jats:italic>and we describe a detailed analysis of the molecular epidemiology and phylogeography of<jats:italic>S. mansoni<\/jats:italic>from Lake Victoria. In total, 388 cytochrome oxidase 1 (COI) sequences were obtained from 25 sites along the Ugandan, Tanzanian and Kenyan shorelines of Lake Victoria, and 122 unique barcodes were identified; 9 corresponded to previously discovered barcodes from Lakes Victoria and Albert. A subset of the data, composed of COI sequences from miracidia from 10 individual children, was used for population genetics analyses; these results were corroborated by microsatellite analysis of 4 isolates of lab-passaged adult worms. Overall, 12 barcodes were found to be shared across all 3 countries, whereas the majority occurred singly and were locally restricted. The population genetics analyses were in agreement in revealing high diversity at the level of the human host and negligible population structuring by location. The lack of correlation between genetic distance and geographical distance in these data may be attributed to the confounding influence of high intra-individual diversity as well as human migration between communities.<\/jats:p>","DOI":"10.1017\/s0031182010000788","type":"journal-article","created":{"date-parts":[[2010,6,21]],"date-time":"2010-06-21T08:17:06Z","timestamp":1277108226000},"page":"1937-1949","source":"Crossref","is-referenced-by-count":34,"title":["Molecular epidemiology and phylogeography of<i>Schistosoma mansoni<\/i>around Lake Victoria"],"prefix":"10.1017","volume":"137","author":[{"given":"C. J.","family":"STANDLEY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. B.","family":"KABATEREINE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. N.","family":"LANGE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. J. S.","family":"LWAMBO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"STOTHARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,6,21]]},"reference":[{"key":"S0031182010000788_ref32","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991600"},{"key":"S0031182010000788_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2005.02443.x"},{"key":"S0031182010000788_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msm092"},{"key":"S0031182010000788_ref28","doi-asserted-by":"publisher","DOI":"10.1080\/00222939700770361"},{"key":"S0031182010000788_ref23","doi-asserted-by":"publisher","DOI":"10.4081\/gh.2009.209"},{"key":"S0031182010000788_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009990412"},{"key":"S0031182010000788_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1096-3642.2007.00330.x"},{"key":"S0031182010000788_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.0014-3820.2004.tb01587.x"},{"key":"S0031182010000788_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2006.03.002"},{"key":"S0031182010000788_ref10","first-page":"47","article-title":"Arlequin ver. 3.0: An integrated software package for population genetics data analysis","volume":"1","author":"Excoffier","year":"2005","journal-title":"Evolutionary Bioinformatics Online"},{"key":"S0031182010000788_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/mollus\/62.2.165"},{"key":"S0031182010000788_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.12.013"},{"key":"S0031182010000788_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00031-0"},{"key":"S0031182010000788_ref12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/genetics\/147.2.915","article-title":"Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection","volume":"147","author":"Fu","year":"1997","journal-title":"Genetics"},{"key":"S0031182010000788_ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009991272"},{"key":"S0031182010000788_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182002002020"},{"key":"S0031182010000788_ref5","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4269\/ajtmh.2003.68.456","article-title":"Urinary tract pathology attributed to Schistosoma haematobium: Does parasite genetics play a role","volume":"68","author":"Brouwer","year":"2003","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0031182010000788_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182006001685"},{"key":"S0031182010000788_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009005940"},{"key":"S0031182010000788_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00037-2"},{"key":"S0031182010000788_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-007-0476-0"},{"key":"S0031182010000788_ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-8278.2001.00042.x"},{"key":"S0031182010000788_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2005.02709.x"},{"key":"S0031182010000788_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2003.11.026"},{"key":"S0031182010000788_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s002850100092"},{"key":"S0031182010000788_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200999031X"},{"key":"S0031182010000788_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.04.010"},{"key":"S0031182010000788_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0031182010000788_ref30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/genetics\/123.3.585","article-title":"Statistical method for testing the neutral mutation hypothesis by DNA polymorphism","volume":"123","author":"Tajima","year":"1989","journal-title":"Genetics"},{"key":"S0031182010000788_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200900643X"},{"key":"S0031182010000788_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.05.001"},{"key":"S0031182010000788_ref8","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1111\/j.1365-294X.2009.04388.x","article-title":"Contrasting mtDNA diversity and population structure in a direct-developing marine gastropod and its trematode parasites","volume":"18","author":"Devon","year":"2009","journal-title":"Molecular Ecology"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182010000788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T21:39:07Z","timestamp":1635543547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182010000788\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,21]]},"references-count":32,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0031182010000788"],"URL":"https:\/\/doi.org\/10.1017\/s0031182010000788","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,21]]}}}