{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:56:08Z","timestamp":1774353368790,"version":"3.50.1"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T00:00:00Z","timestamp":1289865600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Praziquantel is the cornerstone of schistosomiasis control. A number of reports from endemic areas suggest that resistance or tolerance to praziquantel might exist in<jats:italic>Schistosoma mansoni.<\/jats:italic>Several explanations were postulated. The present work was designed to test the hypothesis that a low praziquantel (pzq) cure rate in Egypt is due to survival and maturation of immature stages that escaped pzq, which is effective against mature<jats:italic>S. mansoni<\/jats:italic>worms only. The study sample included 1351 children attending El Rouse primary school located in El Rouse village, Nile Delta, Egypt. All children received 2 pzq doses (40 mg\/kg) 4 weeks apart. Diagnosis of<jats:italic>S. mansoni<\/jats:italic>infection and cure assessment were based on examination of 2 Kato slides prepared from a single stool sample collected before and 4 weeks after the first and second treatments. The cure rate was 78\u00b78% after the first treatment and increased significantly to 90\u00b78% after the second treatment. Egg reduction rates were 71\u00b72% and 77\u00b72% after 1 and 2 treatments respectively. Pre-treatment intensity of infection has a great influence on cure and egg reduction rates. Our results confirmed that low praziquantel cure rate, in Egypt, might be attributed, even partially, to survival and maturation of the immature<jats:italic>S. mansoni<\/jats:italic>stages that escaped pzq that is effective against mature worms only.<\/jats:p>","DOI":"10.1017\/s003118201000154x","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T11:17:35Z","timestamp":1289906255000},"page":"440-446","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of two praziquantel treatments among primary school children in an area of high<i>Schistosoma mansoni<\/i>endemicity, Nile Delta, Egypt"],"prefix":"10.1017","volume":"138","author":[{"given":"RASHIDA","family":"BARAKAT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HALA EL","family":"MORSHEDY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,11,16]]},"reference":[{"key":"S003118201000154X_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/151.6.1130"},{"key":"S003118201000154X_ref30","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.760"},{"key":"S003118201000154X_ref27","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.167"},{"key":"S003118201000154X_ref26","first-page":"532","article-title":"Intestinal schistosomiasis among children in a labour village of Wonji Sugar Estate, Ethiopia","volume":"67","author":"Simonen","year":"1990","journal-title":"East African Medical Journal"},{"key":"S003118201000154X_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(88)90282-9"},{"key":"S003118201000154X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.03.010"},{"key":"S003118201000154X_ref16","volume-title":"Quantification of disease burden due to schistosomiasis.TDR\/SWG\/07","author":"King","year":"2007"},{"key":"S003118201000154X_ref15","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.214"},{"key":"S003118201000154X_ref8","first-page":"367","volume-title":"Human Schistosomiasis","author":"Davis","year":"1993"},{"key":"S003118201000154X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)02209-7"},{"key":"S003118201000154X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(65)90037-8"},{"key":"S003118201000154X_ref4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4049\/jimmunol.139.1.215","article-title":"The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response","volume":"139","author":"Brindley","year":"1987","journal-title":"Journal of Immunology"},{"key":"S003118201000154X_ref1","first-page":"259","article-title":"Schistosoma mansoni in the Nile Delta, Egypt. 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