{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T13:48:00Z","timestamp":1652795280755},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T00:00:00Z","timestamp":1297728000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This study assessed the impact of adding community-directed treatment (ComDT) to the routine health facility (HF)-based treatment on prevalence and intensity of soil transmitted helminth (STH) infections among children aged 12 to 59 months. Repeated cross-sectional surveys were conducted among randomly selected children of this age group from the intervention area (HF+ComDT area) and the comparison area (HF area) at baseline (<jats:italic>n<\/jats:italic>=986), 12 months (<jats:italic>n<\/jats:italic>=796) and 18 months (<jats:italic>n<\/jats:italic>=788) follow-up. The prevalence of <jats:italic>Ascaris lumbricoides<\/jats:italic> was significantly higher in the HF+ComDT as compared to the HF area at baseline (<jats:italic>P<\/jats:italic>=0\u00b7048), but not at 12 and 18 months follow-up. At baseline the HF+ComDT area had significantly higher intensities of <jats:italic>A. lumbricoides<\/jats:italic> compared to the HF area (<jats:italic>P<\/jats:italic>&lt;0\u00b7001), but not at 12 and 18 months follow-ups. Prevalence and intensity of hookworm did not differ significantly between treatment arms at any time. Analysis of trends showed a significant decrease in prevalence of <jats:italic>A. lumbricoides<\/jats:italic> and hookworm in the HF+ComDT area (<jats:italic>P<\/jats:italic>&lt;0\u00b7001), of hookworm in the HF area (<jats:italic>P<\/jats:italic>&lt;0\u00b705), but not of <jats:italic>A. lumbricoides<\/jats:italic> in the HF area. It is concluded that the ComDT approach generally enhanced the treatment effect among under-five year children and that this alternative approach may also have advantages in other geographical settings.<\/jats:p>","DOI":"10.1017\/s0031182011000059","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T17:27:41Z","timestamp":1297790861000},"page":"1578-1585","source":"Crossref","is-referenced-by-count":8,"title":["Impact of community-directed treatment on soil transmitted helminth infections in children aged 12 to 59 months in Mazabuka District, Zambia"],"prefix":"10.1017","volume":"138","author":[{"given":"HIKABASA","family":"HALWINDI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PASCAL","family":"MAGNUSSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SETER","family":"SIZIYA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAY","family":"HANDEMA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAN W.","family":"MEYROWITSCH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANNETTE","family":"OLSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"S0031182011000059_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90370-9"},{"key":"S0031182011000059_ref18","unstructured":"TDR (2008). Community-directed interventions for major health problems in Africa. A multi-country study final report. UNICEF\/UNDP\/World Bank\/WHO."},{"key":"S0031182011000059_ref2","first-page":"343","article-title":"Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar","volume":"81","author":"Albonico","year":"2003","journal-title":"Bulletin of the World Health Organization"},{"key":"S0031182011000059_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0720-048X(96)01029-7"},{"key":"S0031182011000059_ref25","first-page":"145","article-title":"Schistosomiasis and soil-transmitted helminth infections \u2013 preliminary estimates of the number of children treated with albendazole or mebendazole","volume":"81","year":"2006","journal-title":"Weekly epidemiological record"},{"key":"S0031182011000059_ref26","unstructured":"WHO & UNICEF (2004). How to add deworming to vitamin A distribution. Geneva: World Health Organization."},{"key":"S0031182011000059_ref10","unstructured":"Halwindi H. (2010). Community-directed treatment of soil transmitted helminths in children aged 12 to 59 months of Mazabuka district in Zambia. PhD thesis, University of Copenhagen."},{"key":"S0031182011000059_ref13","unstructured":"Ministry of Health\/Central Board of Health. (2003). National plan of action for control of schistosomiasis in Zambia. MoH\/CBoH, Zambia."},{"key":"S0031182011000059_ref3","unstructured":"APOC (1998). Community-directed treatment with ivermectin: A practical guide for trainers of community-directed distributors. APOC, Ouagadougou"},{"key":"S0031182011000059_ref12","first-page":"1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008","journal-title":"Journal of the American Medical Association"},{"key":"S0031182011000059_ref24","unstructured":"WHO (2006 a). Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions. A manual for health professionals and programme managers."},{"key":"S0031182011000059_ref7","volume-title":"Handbook of Helminthiasis for Public Health","author":"Crompton","year":"2007"},{"key":"S0031182011000059_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61422-7"},{"key":"S0031182011000059_ref5","first-page":"98","article-title":"A simplified general method for cluster-sample surveys of health in developing countries","volume":"44","author":"Bennett","year":"1991","journal-title":"World Health Statistics Quarterly"},{"key":"S0031182011000059_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182008004836"},{"key":"S0031182011000059_ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000126"},{"key":"S0031182011000059_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.inhe.2010.09.003"},{"key":"S0031182011000059_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2004.02.006"},{"key":"S0031182011000059_ref22","unstructured":"WHO (2004). Bench aids for diagnosis of intestinal helminths. World Health Organization, Geneva."},{"key":"S0031182011000059_ref23","unstructured":"WHO (2005). Report of the third global meeting of the partners for parasite control: Deworming for health and development. Geneva 29\u201330 November 2004."},{"key":"S0031182011000059_ref21","unstructured":"WHO (2002). Helminth control in school-age children. A guide to managers of control programmes. World Health Organization, Geneva."},{"key":"S0031182011000059_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.2.348"},{"key":"S0031182011000059_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(00)01779-8"},{"key":"S0031182011000059_ref20","unstructured":"WHO (1999). Monitoring Helminth Control Programs, WHO\/CDS\/CPC\/SIP\/99.3."},{"key":"S0031182011000059_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00042-1"},{"key":"S0031182011000059_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(94)00341-P"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182011000059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T04:46:35Z","timestamp":1556340395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182011000059\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,15]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0031182011000059"],"URL":"https:\/\/doi.org\/10.1017\/s0031182011000059","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,15]]}}}