{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T14:40:16Z","timestamp":1712241616756},"reference-count":57,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T00:00:00Z","timestamp":1298505600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The underlying mechanism of predisposition to<jats:italic>Ascaris<\/jats:italic>infection is not yet understood but host genetics are thought to play a fundamental role. We investigated the association between the Intelectin-2 gene and resistance in F<jats:sub>2<\/jats:sub>mice derived from mouse strains known to be susceptible and resistant to infection.<jats:italic>Ascaris<\/jats:italic>larvae were isolated from murine lungs and the number of copies of the Intelectin-2 gene was determined in F<jats:sub>2<\/jats:sub>mice. Intelectin-2 gene copy number was not significantly linked to larval burden. In a pilot experiment, the response to infection in parental mice of both sexes was observed in order to address the suitablity of female F<jats:sub>2<\/jats:sub>mice. No overall significant sex effect was detected. However, a divergence in resistance\/susceptibility status was observed between male and, female hybrid offspring. The responsiveness to<jats:italic>Ascaris<\/jats:italic>in mice is likely to be controlled by multiple genes and, despite a unique absence from the susceptible C57BL\/6j strain, the Intelectin-2 gene does not play a significant role in resistance. The observed intra-strain variation in larval burden requires further investigation but we hypothesize that it stems from social\/dominance hierarchies created by the presence of female mice and possibly subsequent hormonal perturbations that modify the intensity of the immune response.<\/jats:p>","DOI":"10.1017\/s0031182011000084","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T15:12:03Z","timestamp":1298560323000},"page":"660-669","source":"Crossref","is-referenced-by-count":3,"title":["The role of Intelectin-2 in resistance to<i>Ascaris suum<\/i>lung larval burdens in susceptible and resistant mouse strains"],"prefix":"10.1017","volume":"138","author":[{"given":"CHRISTINA","family":"DOLD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALAN 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