{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:09:55Z","timestamp":1791227395449,"version":"4.1.0"},"reference-count":68,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T00:00:00Z","timestamp":1312329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    In 1994 and 2002, respectively, the World Health Organisation proposed that treatment for hookworm and schistosomiasis could be provided during pregnancy. It was hoped that this might have benefits for maternal anaemia, fetal growth and perinatal mortality; a beneficial effect on the infant response to immunisation was also hypothesised. Three trials have now been conducted. Two have examined the effects of benzimidazoles; one (the Entebbe Mother and Baby Study) the effects of albendazole and praziquantel. All three were conducted in settings of high prevalence but low intensity helminth infection. Results suggest that, in such settings and given adequate provision of haematinics, the benefit of routine anthelminthics during pregnancy for maternal anaemia may be small; none of the other expected benefits has yet been demonstrated. The Entebbe Mother and Baby Study found a significant adverse effect of albendazole on the incidence of infantile eczema in the whole study population, and of praziquantel on the incidence of eczema among infants of mothers with\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    . Further studies are required in settings that differ in helminth species and infection intensities. Further research is required to determine whether increased rates of infantile eczema translate to long-term susceptibility to allergy, and to explore the underlying mechanisms of these effects. The risks and benefits of routine anthelminthic treatment in antenatal clinics may need to be reconsidered.\n                  <\/jats:p>","DOI":"10.1017\/s0031182011001053","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T07:58:54Z","timestamp":1312358334000},"page":"1499-1507","source":"Crossref","is-referenced-by-count":53,"title":["Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?"],"prefix":"10.1017","volume":"138","author":[{"given":"ALISON M.","family":"ELLIOTT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JULIET","family":"NDIBAZZA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HARRIET","family":"MPAIRWE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LAWRENCE","family":"MUHANGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EMILY L.","family":"WEBB","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DENNISON","family":"KIZITO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICE","family":"MAWA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROBERT","family":"TWEYONGYERE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOSES","family":"MUWANGA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,8,3]]},"reference":[{"key":"S0031182011001053_ref44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1992.tb02878.x"},{"key":"S0031182011001053_ref64","unstructured":"WHO (2002). Report of the WHO informal consultation on the use of praziquantel during pregnancy\/lactation and albendazole\/mebendazole in children under 24 months. Geneva, 8\u20139 April 2002. WHO\/CDS\/CPE\/PVC\/2002.4."},{"key":"S0031182011001053_ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"S0031182011001053_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.10.047"},{"key":"S0031182011001053_ref65","unstructured":"WHO (2006). Report of the Scientific Working Group meeting on Schistosomiasis, Geneva, 14\u201316 November, 2005. TDR\/SWG\/07."},{"key":"S0031182011001053_ref67","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.043"},{"key":"S0031182011001053_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)06308-9"},{"key":"S0031182011001053_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90164-6"},{"key":"S0031182011001053_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005547.pub2"},{"key":"S0031182011001053_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.2.286"},{"key":"S0031182011001053_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2004.08.001"},{"key":"S0031182011001053_ref1","doi-asserted-by":"publisher","DOI":"10.1179\/136485905X17407"},{"key":"S0031182011001053_ref8","doi-asserted-by":"publisher","DOI":"10.1086\/429668"},{"key":"S0031182011001053_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17023-2"},{"key":"S0031182011001053_ref41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2010.01122.x"},{"key":"S0031182011001053_ref23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2222.2009.03346.x","article-title":"Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam","volume":"40","author":"Flohr","year":"2010","journal-title":"Clinical Experimental Allergy"},{"key":"S0031182011001053_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69286-6"},{"key":"S0031182011001053_ref43","doi-asserted-by":"publisher","DOI":"10.1086\/649924"},{"key":"S0031182011001053_ref63","unstructured":"WHO (1999). Monitoring Helminth Control Programmes. Guidelines for monitoring the impact of control programmes aimed at reducing morbidity caused by soil-transmitted helminths and schistosomes, with particular reference to school-age children. WHO\/CDS\/CPC\/SIP\/99.3."},{"key":"S0031182011001053_ref30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000442"},{"key":"S0031182011001053_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03559.x"},{"key":"S0031182011001053_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.06.024"},{"key":"S0031182011001053_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90148-6"},{"key":"S0031182011001053_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.03.017"},{"key":"S0031182011001053_ref33","doi-asserted-by":"crossref","first-page":"783","DOI":"10.4269\/ajtmh.2005.73.783","article-title":"Relationship between intensity of soil-transmitted helminth infections and anemia during pregnancy","volume":"73","author":"Larocque","year":"2005","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0031182011001053_ref66","volume-title":"Asthma Facts","year":"2010"},{"key":"S0031182011001053_ref15","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.79"},{"key":"S0031182011001053_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03134.x"},{"key":"S0031182011001053_ref45","first-page":"CD004736","article-title":"Effects of routine oral iron supplementation with or without folic acid for women during pregnancy","volume":"3","author":"Pena-Rosas","year":"2006","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0031182011001053_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01706.x"},{"key":"S0031182011001053_ref20","first-page":"2032","article-title":"Helminth infection during pregnancy and development of infantile eczema","volume":"294","author":"Elliott","year":"2005","journal-title":"Journal of the American Medical Association"},{"key":"S0031182011001053_ref62","unstructured":"WHO (1995). Report of the WHO informal consultation on hookworm infection and anaemia in girls and women. Geneva, 5\u20137 December 1994. WHO\/CTD\/SIP\/96.1."},{"key":"S0031182011001053_ref38","doi-asserted-by":"crossref","first-page":"6843","DOI":"10.4049\/jimmunol.162.11.6843","article-title":"Helminth- and Bacillus Calmette-Guerin-induced immunity in children sensitized in utero to filariasis and schistosomiasis","volume":"162","author":"Malhotra","year":"1999","journal-title":"Journal of Immunology"},{"key":"S0031182011001053_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(90)90227-U"},{"key":"S0031182011001053_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90009-4"},{"key":"S0031182011001053_ref12","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-143-6-2003"},{"key":"S0031182011001053_ref47","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1966.15.1032"},{"key":"S0031182011001053_ref46","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00131-10"},{"key":"S0031182011001053_ref53","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-32"},{"key":"S0031182011001053_ref58","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.017228"},{"key":"S0031182011001053_ref50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000682"},{"key":"S0031182011001053_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/27.3.530"},{"key":"S0031182011001053_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(02)02386-3"},{"key":"S0031182011001053_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1280s"},{"key":"S0031182011001053_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01098.x"},{"key":"S0031182011001053_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68697-2"},{"key":"S0031182011001053_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00031-7"},{"key":"S0031182011001053_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328318978f"},{"key":"S0031182011001053_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/1740774506075248"},{"key":"S0031182011001053_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)90040-X"},{"key":"S0031182011001053_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.02.006"},{"key":"S0031182011001053_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.778"},{"key":"S0031182011001053_ref29","first-page":"1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008","journal-title":"Journal of the American Medical Association"},{"key":"S0031182011001053_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92661-K"},{"key":"S0031182011001053_ref35","first-page":"514","article-title":"Asthma and current intestinal parasite infection: systematic review and meta-analysis","volume":"174","author":"Leonardi-Bee","year":"2006","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0031182011001053_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(93)90119-Z"},{"key":"S0031182011001053_ref39","doi-asserted-by":"publisher","DOI":"10.1086\/500472"},{"key":"S0031182011001053_ref40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119340"},{"key":"S0031182011001053_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90035-3"},{"key":"S0031182011001053_ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0085-3"},{"key":"S0031182011001053_ref54","doi-asserted-by":"publisher","DOI":"10.1086\/593215"},{"key":"S0031182011001053_ref55","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182001007752"},{"key":"S0031182011001053_ref56","doi-asserted-by":"publisher","DOI":"10.1086\/381767"},{"key":"S0031182011001053_ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2007.03.009"},{"key":"S0031182011001053_ref59","first-page":"1660","article-title":"Increased risk of allergy associated with the use of kerosene fuel in the home","volume":"164","author":"Venn","year":"2001","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0031182011001053_ref60","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981646"},{"key":"S0031182011001053_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61457-2"},{"key":"S0031182011001053_ref68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000473"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182011001053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T10:09:29Z","timestamp":1712657369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182011001053\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,3]]},"references-count":68,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0031182011001053"],"URL":"https:\/\/doi.org\/10.1017\/s0031182011001053","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,3]]}}}