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A number of serpins have now been identified in parasitic helminths with putative involvement in immune regulation and in parasite survival through interference with the host immune response. This review describes the serpins and smapins (small serine protease inhibitors) that have been identified in<jats:italic>Ascaris<\/jats:italic>spp.,<jats:italic>Brugia malayi, Ancylostoma caninum Onchocerca volvulus, Haemonchus contortus, Trichinella spiralis, Trichostrongylus vitrinus, Anisakis simplex, Trichuris suis, Schistosoma<\/jats:italic>spp.,<jats:italic>Clonorchis sinensis, Paragonimus westermani<\/jats:italic>and<jats:italic>Echinococcus<\/jats:italic>spp. and discusses their possible biological functions, including roles in host-parasite interplay and their evolutionary relationships.<\/jats:p>","DOI":"10.1017\/s0031182011002435","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T15:21:51Z","timestamp":1328541711000},"page":"681-695","source":"Crossref","is-referenced-by-count":95,"title":["Serine protease inhibitors of parasitic helminths"],"prefix":"10.1017","volume":"139","author":[{"given":"ADEBAYO 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