{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:02:53Z","timestamp":1780675373897,"version":"3.54.1"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>This study aimed to investigate myocardial injuries in mice infected with <jats:italic>Schistosoma mansoni<\/jats:italic> and fed a high-fat chow. Sections of myocardial tissue from <jats:italic>S. mansoni<\/jats:italic>-infected mice, and controls that had been killed 9 and 17 weeks post-infection, were stained with H&amp;E and Picrosirius red. Histopathological examination, stereological design-based method (optical disector) and morphometry (vessels, cardiomyocytes and an amount of collagen) were used. Data were analysed using two-way ANOVA. Regardless of time of infection, myocardial tissue from the infected mice fed high-fat chow showed myocarditis characterized by a higher number of inflammatory foci, several areas displaying coagulation of cardiac fibres, a greater loss of cardiomyocytes and fibroblast proliferation than in the standard chow control. Comparing infected mice from acute and chronic infections, a higher cardiomyocyte hyperplasia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001) and higher amounts of collagen (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) were observed than in standard chow control. In addition, all animals fed high-fat chow showed lower numerical density and total number of cardiomyocytes (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705), thicker vessel walls and narrowed luminal intramyocardial vessels (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00\u00b705) than in the standard chow control. Altogether the data supported the view that a double burden has a synergistic deleterious effect on the myocardial tissue.<\/jats:p>","DOI":"10.1017\/s0031182012000807","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T04:20:34Z","timestamp":1349151634000},"page":"1462-1470","source":"Crossref","is-referenced-by-count":4,"title":["Effects of high-fat chow on heart tissue in acute and chronic experimental murine schistosomiasis mansoni"],"prefix":"10.1017","volume":"139","author":[{"given":"V. C.","family":"G\u00d3ES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H.","family":"NEVES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. M. B.","family":"ALENCAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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