{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:34:24Z","timestamp":1792640064738,"version":"4.5.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The lack of an adequate model for<jats:italic>Leishmania<\/jats:italic>(<jats:italic>Viannia<\/jats:italic>)<jats:italic>braziliensis<\/jats:italic>infection is a limiting factor for studying American tegumentary leishmaniasis (ATL). The golden hamster (<jats:italic>Mesocricetus auratus<\/jats:italic>) is a promising model because besides being highly susceptible to dermotropic<jats:italic>Leishmania<\/jats:italic>infection, the lesions are very similar to cutaneous leishmaniasis (CL) in humans. However, different<jats:italic>Leishmania<\/jats:italic>isolates or species and\/or protocols have resulted in different outcomes, whereas no study has evaluated the reproducibility of<jats:italic>L. braziliensis<\/jats:italic>infection in this model. The natural history of<jats:italic>L. braziliensis<\/jats:italic>infection in 34 hamsters was evaluated by using a single parasite isolate in 8 independent experiments under similar experimental conditions. Clinical, histological and immunological analyses were performed. The hamsters presented skin ulcers similar to those observed in ATL. The intra-experiment lesion increment tended to show an intermediary variance. Histological analysis of infected skins showed granulomatous reaction, scarce amastigotes, and Schaumann's bodies. Blood lymphocytes proliferated in response to leishmanial antigens. The severity of the infection was positively correlated to spleen weight, and the titres of anti-<jats:italic>Leishmania<\/jats:italic>IgG antibodies. Our findings indicate that the hamster is an appropriate model for immunopathogenesis studies of CL caused by<jats:italic>L. braziliensis<\/jats:italic>, supporting its use in clinical, vaccine and chemotherapy experimental protocols.<\/jats:p>","DOI":"10.1017\/s0031182012002156","type":"journal-article","created":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T16:49:34Z","timestamp":1359737374000},"page":"771-779","source":"Crossref","is-referenced-by-count":53,"title":["Golden hamster (<i>Mesocricetus auratus<\/i>) as an experimental model for<i>Leishmania<\/i>(<i>Viannia<\/i>)<i>braziliensis<\/i>infection"],"prefix":"10.1017","volume":"140","author":[{"given":"ADRIANO","family":"GOMES-SILVA","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOANNA GARDEL","family":"VALVERDE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAQUEL PERALVA","family":"RIBEIRO-ROM\u00c3O","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROSA MARIA","family":"PL\u00c1CIDO-PEREIRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ALDA MARIA","family":"DA-CRUZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"S0031182012002156_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(80)90227-8"},{"key":"S0031182012002156_ref36","doi-asserted-by":"publisher","DOI":"10.2307\/3282237"},{"key":"S0031182012002156_ref34","volume-title":"Casos de leishmaniose tegumentar Americana. 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