{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:07:13Z","timestamp":1791018433656,"version":"4.1.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>\n                    Anti-\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    therapy delivers safe macrofilaricidal activity with superior therapeutic outcomes compared to all standard anti-filarial treatments, with the added benefit of substantial improvements in clinical pathology. These outcomes can be achieved, in principle, with existing registered drugs, e.g. doxycycline, that are affordable, available to endemic communities and have well known, albeit population-limiting, safety profiles. The key barriers to using doxycycline as an mass drug administration (MDA) strategy for widespread community-based control are the logistics of a relatively lengthy course of treatment (4\u20136 weeks) and contraindications in children under eight years and pregnancy. Therefore, the primary goal of the anti-\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    (A\u00b7WOL) consortium is to find drugs and regimens that reduce the period of treatment from weeks to days (7 days or less), and to find drugs which would be safe in excluded target populations (pregnancy and children). A secondary goal is to refine regimens of existing antibiotics suitable for a more restricted use, prior to the availability of a regimen that is compatible with MDA usage. For example, for use in the event of the emergence of drug-resistance, in individuals with high loiasis co-infection and at risk of severe adverse events (SAE) to ivermectin, or in post-MDA \u2018endgame scenarios\u2019, where test and treat strategies become more cost effective and deliverable.\n                  <\/jats:p>","DOI":"10.1017\/s0031182013001108","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T10:30:48Z","timestamp":1374143448000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":137,"title":["Anti-\n                    <i>Wolbachia<\/i>\n                    drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis"],"prefix":"10.1017","volume":"141","author":[{"given":"MARK J.","family":"TAYLOR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ACHIM","family":"HOERAUF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SIMON","family":"TOWNSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BARTON E.","family":"SLATKO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN A.","family":"WARD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"S0031182013001108_ref36","unstructured":"World Health Organisation (2012). Accelerating work to overcome the global impact of neglected tropical diseases \u2013 A roadmap for implementation WHO\/HTM\/NTD\/2012.1."},{"key":"S0031182013001108_ref34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304049110"},{"key":"S0031182013001108_ref32","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-2-39"},{"key":"S0031182013001108_ref31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203519109"},{"key":"S0031182013001108_ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2883-5-4"},{"key":"S0031182013001108_ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-2-7"},{"key":"S0031182013001108_ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-5-53"},{"key":"S0031182013001108_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-009-1624-5"},{"key":"S0031182013001108_ref18","doi-asserted-by":"publisher","DOI":"10.1179\/136485908X337454"},{"key":"S0031182013001108_ref29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.2.1240"},{"key":"S0031182013001108_ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000998"},{"key":"S0031182013001108_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2004.01.006"},{"key":"S0031182013001108_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.10.003"},{"key":"S0031182013001108_ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002351"},{"key":"S0031182013001108_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1756-3305-3-99"},{"key":"S0031182013001108_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328315cde7"},{"key":"S0031182013001108_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020092"},{"key":"S0031182013001108_ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002032"},{"key":"S0031182013001108_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000708"},{"key":"S0031182013001108_ref1","doi-asserted-by":"publisher","DOI":"10.1179\/136485908X337436"},{"key":"S0031182013001108_ref30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M901528200"},{"key":"S0031182013001108_ref19","first-page":"S2","article-title":"Report of a Scientific Working Group on Serious Adverse Events following Mectizan(R) treatment of onchocerciasis in Loa loa endemic areas","volume":"2","year":"2003","journal-title":"Filaria Journal"},{"key":"S0031182013001108_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis486"},{"key":"S0031182013001108_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(05)60004-8"},{"key":"S0031182013001108_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12084"},{"key":"S0031182013001108_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s13199-010-0067-1"},{"key":"S0031182013001108_ref8a","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4768"},{"key":"S0031182013001108_ref22","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00057-10"},{"key":"S0031182013001108_ref2","doi-asserted-by":"publisher","DOI":"10.2307\/3277515"},{"key":"S0031182013001108_ref33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000475"},{"key":"S0031182013001108_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.11.009"},{"key":"S0031182013001108_ref35","unstructured":"World Health Organisation (2010). GPELF Progress Report 2000\u20132009 and Strategic Plan 2010\u20132020. WHO\/HTM\/NTD\/PCT\/2010.6."},{"key":"S0031182013001108_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60586-7"},{"key":"S0031182013001108_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32833fdee5"},{"key":"S0031182013001108_ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030121"},{"key":"S0031182013001108_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-243"},{"key":"S0031182013001108_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.04.014"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182013001108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T20:57:42Z","timestamp":1555966662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182013001108\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0031182013001108"],"URL":"https:\/\/doi.org\/10.1017\/s0031182013001108","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2013\u00a0The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence <http:\/\/creativecommons.org\/licenses\/by\/3.0\/>.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}