{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:44:31Z","timestamp":1782798271260,"version":"3.54.5"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"13","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In the eastern Tibetan plateau both human cystic and alveolar echinococcosis (AE) caused by infection with <jats:italic>Echincoccus granulosus<\/jats:italic> or <jats:italic>Echinococcus multilocularis<\/jats:italic>, respectively are highly endemic. The domestic dog plays a key role in zoonotic transmission in this region. Our primary objective was to investigate the role of domestic dogs in maintaining transmission of <jats:italic>E. multilocularis<\/jats:italic> in Shiqu county, Sichuan. A cohort of 281 dogs was followed up over one year after a single treatment with praziquantel followed by re-infection surveillance at 2, 5 and 12 months post-treatment. Faecal samples were tested by an <jats:italic>Echinococcus<\/jats:italic> genus-specific coproantigen ELISA and two species-specific copro-PCR tests. Total <jats:italic>Echinococcus<\/jats:italic> coproantigen prevalence in Shiqu at baseline was 21% and 9\u00b76% after 2 months. <jats:italic>E. multilocularis<\/jats:italic> copro-PCR was positive in 11\u00b72% of dogs before treatment (<jats:italic>vs<\/jats:italic> 3\u00b76% with <jats:italic>E. granulosus<\/jats:italic> copro-DNA), 2\u00b79% at 2 months post-treatment, and 0% at 5 month and 12 months. The results suggest that dogs may have the potential to maintain <jats:italic>E. multilocularis<\/jats:italic> transmission within local pastoral communities, and thus dog dosing could be an effective strategy to reduce transmission of <jats:italic>E. multilocularis<\/jats:italic> as well as <jats:italic>E. granulosus<\/jats:italic> in these co-endemic Tibetan communities.<\/jats:p>","DOI":"10.1017\/s0031182013001200","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T09:40:44Z","timestamp":1377682844000},"page":"1685-1692","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":44,"title":["Reinfection studies of canine echinococcosis and role of dogs in transmission of <i>Echinococcus multilocularis<\/i> in Tibetan communities, Sichuan, China"],"prefix":"10.1017","volume":"140","author":[{"given":"J. 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