{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:58:49Z","timestamp":1771477129407,"version":"3.50.1"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2013,10,22]],"date-time":"2013-10-22T00:00:00Z","timestamp":1382400000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Due to an increasing demand for natural products to control coccidiosis in broilers, we investigated the effects of supplementing a combination of ethanolic extracts of<jats:italic>Artemisia annua<\/jats:italic>and<jats:italic>Curcuma longa<\/jats:italic>in drinking water. Three different dosages of this herbal mixture were compared with a negative control (uninfected), a positive control (infected and untreated), chemical coccidiostats (nicarbazin+narazin and, later, salinomycin), vaccination, and a product based on oregano. Differences in performance (weight gain, feed intake, and feed conversion rate), mortality, gross intestinal lesions and oocyst excretion were investigated. Broilers given chemical coccidiostats performed better than all other groups. Broilers given the two highest dosages of the herbal mixture had intermediate lesion scores caused by<jats:italic>Eimeria acervulina<\/jats:italic>, which was higher than in broilers given coccidiostats, but less than in broilers given vaccination, oregano and in negative controls. There was a trend for lower mortality (<jats:italic>P<\/jats:italic>= 0\u00b708) in the later stage of the growing period (23\u201343 days) in broilers given the highest dosage of herbal mixture compared with broilers given chemical coccidiostats. In conclusion, the delivery strategy of the herbal extracts is easy to implement at farm level, but further studies on dose levels and modes of action are needed.<\/jats:p>","DOI":"10.1017\/s0031182013001443","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T11:41:45Z","timestamp":1382528505000},"page":"347-355","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["The effects of combining<i>Artemisia annua<\/i>and<i>Curcuma longa<\/i>ethanolic extracts in broilers challenged with infective oocysts of<i>Eimeria acervulina<\/i>and<i>E. maxima<\/i>"],"prefix":"10.1017","volume":"141","author":[{"given":"GUSTAVO F. D.","family":"ALMEIDA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"STIG M.","family":"THAMSBORG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALDA M. B. N.","family":"MADEIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JORGE F. S.","family":"FERREIRA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PEDRO M.","family":"MAGALH\u00c3ES","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LUIZ C. DEMATT\u00ca","family":"FILHO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KLAUS","family":"HORSTED","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOHN E.","family":"HERMANSEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,10,22]]},"reference":[{"key":"S0031182013001443_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0043933912000268"},{"key":"S0031182013001443_ref8","volume-title":"Diagnosis of Coccidiosis in Chickens","year":"1990"},{"key":"S0031182013001443_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/pca.1101"},{"key":"S0031182013001443_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-006-4390-8"},{"key":"S0031182013001443_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(05)60005-X"},{"key":"S0031182013001443_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.02.013"},{"key":"S0031182013001443_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.11.051"},{"key":"S0031182013001443_ref54","volume-title":"SAS Online Doc\u00ae, Version 9.2","year":"2000"},{"key":"S0031182013001443_ref43","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.5.1859-1860.2006"},{"key":"S0031182013001443_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(97)00027-1"},{"key":"S0031182013001443_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0065-2571(91)90025-H"},{"key":"S0031182013001443_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.07.005"},{"key":"S0031182013001443_ref38","unstructured":"Mathis G. F. (2005). Reasons for field problems with E. maxima: E. acervulina vs E. maxima. In Proceeding of the IXth International Coccidiosis Conference, Foz do Iguac\u00fa, Brazil. 19\u201323 Sept 2005."},{"key":"S0031182013001443_ref39","doi-asserted-by":"publisher","DOI":"10.2307\/1592347"},{"key":"S0031182013001443_ref64","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00086-7"},{"key":"S0031182013001443_ref35","doi-asserted-by":"publisher","DOI":"10.1080\/03079459308418897"},{"key":"S0031182013001443_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.11.058"},{"key":"S0031182013001443_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.11.015"},{"key":"S0031182013001443_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/76.8.1156"},{"key":"S0031182013001443_ref9","first-page":"136","article-title":"Effects of local gametocyte and livacox vaccines on live body weight gain and lymphoid organs in chickens","volume":"28","author":"Anwar","year":"2008","journal-title":"Pakistan Veterinary Journal"},{"key":"S0031182013001443_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.11.059"},{"key":"S0031182013001443_ref47","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3923\/ijps.2006.723.730","article-title":"Essential oils on mixed coccidia vaccination and infection in broilers","volume":"5","author":"Oviedo-Rond\u00f3n","year":"2006","journal-title":"International Journal of Poultry Science"},{"key":"S0031182013001443_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(93)90137-5"},{"key":"S0031182013001443_ref50","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511806384"},{"key":"S0031182013001443_ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0382-x"},{"key":"S0031182013001443_ref57","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-89131998000200008"},{"key":"S0031182013001443_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.09.024"},{"key":"S0031182013001443_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(70)90063-9"},{"key":"S0031182013001443_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00203-3"},{"key":"S0031182013001443_ref26","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000077362"},{"key":"S0031182013001443_ref51","first-page":"259","article-title":"Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound","volume":"55","author":"Rao","year":"1995","journal-title":"Cancer Research"},{"key":"S0031182013001443_ref62","doi-asserted-by":"publisher","DOI":"10.1080\/09064700310007977"},{"key":"S0031182013001443_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2418-0"},{"key":"S0031182013001443_ref22","first-page":"103","volume-title":"Biotechnology. Guidelines of Techniques in Coccidiosis Research","author":"Eckert","year":"1995"},{"key":"S0031182013001443_ref48","first-page":"704","article-title":"Artemisinin-based combination with curcumin adds a new dimension to malaria therapy","volume":"102","author":"Padmanaban","year":"2012","journal-title":"Current Science"},{"key":"S0031182013001443_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(98)00029-0"},{"key":"S0031182013001443_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90183-X"},{"key":"S0031182013001443_ref17","doi-asserted-by":"publisher","DOI":"10.2307\/1591464"},{"key":"S0031182013001443_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(1997)27+<26::AID-JCB7>3.0.CO;2-3"},{"key":"S0031182013001443_ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-009-1535-5"},{"key":"S0031182013001443_ref30","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365233"},{"key":"S0031182013001443_ref49","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/77.2.185"},{"key":"S0031182013001443_ref53","doi-asserted-by":"publisher","DOI":"10.1002\/9783527615353.ch8"},{"key":"S0031182013001443_ref18","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1128\/IAI.56.4.972-976.1988","article-title":"Passive protection of chickens against Eimeria tenella infection by monoclonal antibody","volume":"56","author":"Crane","year":"1988","journal-title":"Infection and Immunity"},{"key":"S0031182013001443_ref19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01238-06"},{"key":"S0031182013001443_ref65","first-page":"755","article-title":"Fifty years of anticoccidial vaccines for poultry, 1952\u20132002","volume":"46","author":"Williams","year":"2002","journal-title":"Avian Disease"}],"container-title":["Parasitology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0031182013001443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T15:09:23Z","timestamp":1596726563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0031182013001443\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,22]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0031182013001443"],"URL":"https:\/\/doi.org\/10.1017\/s0031182013001443","relation":{},"ISSN":["0031-1820","1469-8161"],"issn-type":[{"value":"0031-1820","type":"print"},{"value":"1469-8161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,22]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 2013\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}