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One such promising area for antimalarial drug development has been the parasite mitochondrial electron transport chain (ETC). Efforts have been focused on targeting key processes along the parasite ETC specifically the dihydroorotate dehydrogenase (DHOD) enzyme, the <jats:italic>cytochrome bc<\/jats:italic><jats:sub>1<\/jats:sub> enzyme and the NADH type II oxidoreductase (PfNDH2) pathway. This review summarizes the most recent efforts in antimalarial drug development reported in the literature and describes the evolution of these compounds.<\/jats:p>","DOI":"10.1017\/s0031182013001571","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T08:46:46Z","timestamp":1389170806000},"page":"50-65","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":33,"title":["Novel inhibitors of the <i>Plasmodium falciparum<\/i> electron transport chain"],"prefix":"10.1017","volume":"141","author":[{"given":"P. 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