{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:35:09Z","timestamp":1761489309193},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T00:00:00Z","timestamp":1391644800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Parasitology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The effect of gastrointestinal helminths on Pb accumulation in the host body is ambiguous. A laboratory experiment with<jats:italic>Rattus norvegicus\/Hymenolepis diminuta<\/jats:italic>model was conducted to determine Pb toxicokinetics in a terrestrial host-parasite system. The ET-AAS or ICP\u2013OES techniques were used to determine Pb concentrations (C<jats:sub>Pb<\/jats:sub>) in both tapeworms and host tissues (kidney, liver, bone, testes, muscle and intestinal wall). Concerning the entire host-parasite system, the highest C<jats:sub>Pb<\/jats:sub>were detected in<jats:italic>H. diminuta<\/jats:italic>. Rat kidneys and bone were the only two tissues whose mean Pb levels were lower in parasitized animals than they were in non-infected subjects after both levels of exposure. At low Pb exposure, parasitization slightly changed the Pb toxicokinetics in the host body. However, with respect to tissue at the same exposure level, no significant differences were detected between the parasitized and non-parasitized animals and no significant correlations were found between C<jats:sub>Pb<\/jats:sub>in tapeworms and those of host tissues. The results of this study indicate that<jats:italic>H. diminuta<\/jats:italic>does not protect rat from elevated Pb exposure even if tapeworm accumulates a higher portion of ingested Pb dose compared with that of the most Pb-loaded host soft tissue. The portion of Pb dose accumulated in<jats:italic>H. diminuta<\/jats:italic>correlates positively with parasite biomass.<\/jats:p>","DOI":"10.1017\/s0031182013002242","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T02:41:22Z","timestamp":1391740882000},"page":"826-836","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Is the tapeworm able to affect tissue Pb-concentrations in white rat?"],"prefix":"10.1017","volume":"141","author":[{"given":"ZUZANA","family":"\u010cADKOV\u00c1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DANIELA","family":"MIHOLOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JI\u0158INA","family":"SZ\u00c1KOV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PETR","family":"V\u00c1LEK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IVANA","family":"JANKOVSK\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"IVA","family":"LANGROV\u00c1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,2,6]]},"reference":[{"key":"S0031182013002242_ref16","doi-asserted-by":"publisher","DOI":"10.1051\/analusis:1998121"},{"key":"S0031182013002242_ref41","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020561406624"},{"key":"S0031182013002242_ref7","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1997.273.2.G480"},{"key":"S0031182013002242_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-012-2528-x"},{"key":"S0031182013002242_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00249-7"},{"key":"S0031182013002242_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003003743"},{"key":"S0031182013002242_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-009-9355-2"},{"key":"S0031182013002242_ref6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.24039\/rnh2009321117","article-title":"Overview of the status of heavy metal accumulation by helminths with a note on the use of in vitro culture of adult acanthocephalans to study the mechanisms of bioaccumulation","volume":"3","author":"de Buron","year":"2009","journal-title":"Neotropical Helminthology"},{"key":"S0031182013002242_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00173-4"},{"key":"S0031182013002242_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.10.014"},{"key":"S0031182013002242_ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-004-1232-3"},{"key":"S0031182013002242_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2012.07.006"},{"key":"S0031182013002242_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60070-6"},{"key":"S0031182013002242_ref44","first-page":"85","article-title":"Bioaccumulation and damaging action of polymetal industrial dust on laboratory mice Mus musculus alba \u2013 I. 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