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Using a 2\u00d72 factorial design, pregnant CD1 mice were fed a 24% protein sufficient (PS) or a 6% protein deficient (PD) isoenergetic diet beginning on day 14 of pregnancy and were infected with 100<jats:italic>H. bakeri<\/jats:italic>larvae four times or exposed to four sham infections. On day 20 of lactation, maternal organs were examined histologically and serum analytes were assayed as indicators of organ function. The absence of villus atrophy in response to infection was associated with increased crypt depth and infiltration of mast cells and eosinophils but only in lactating dams fed adequate protein. Infection-induced lobular liver inflammation was reduced in PD dams, however, abnormalities in the kidney caused by protein deficiency were absent in infected dams. Bilirubin and creatinine were highest in PD infected mice. Infection-induced splenomegaly was not due to an increase in the lymphoid compartment of the spleen. During lactation, infection and protein deficiency have interactive effects on extra-intestinal pathologies.<\/jats:p>","DOI":"10.1017\/s0031182013002308","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T16:18:59Z","timestamp":1392049139000},"page":"801-813","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Protein deficiency alters impact of intestinal nematode infection on intestinal, visceral and lymphoid organ histopathology in lactating mice"],"prefix":"10.1017","volume":"141","author":[{"given":"LISA M.","family":"STARR","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MAURICE R.","family":"ODIERE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KRISTINE G.","family":"KOSKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARILYN E.","family":"SCOTT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"key":"S0031182013002308_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00101-7"},{"key":"S0031182013002308_ref63","first-page":"155","article-title":"Correlation of changes in blood chemistry with pathological changes in the animal's body: II electrolytes, kidney function tests, serum enzymes, and liver function tests","volume":"52","author":"Stogdale","year":"1981","journal-title":"Journal of the South African Veterinary Association"},{"key":"S0031182013002308_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01123.x"},{"key":"S0031182013002308_ref55","first-page":"353","article-title":"The role of IgG1 hypergammaglobulinaemia in immunity to the gastrointestinal nematode Nematospiroides dubius. 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